286576

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3969889..3970709 Replicon chromosome
Accession NZ_LR134000
Organism Escherichia coli strain NCTC9066

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag EL014_RS19340 Protein ID WP_001054379.1
Coordinates 3969889..3970146 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag EL014_RS19345 Protein ID WP_000123957.1
Coordinates 3970158..3970709 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL014_RS19320 3965176..3966282 + 1107 WP_001295733.1 N-acetylneuraminate epimerase -
EL014_RS19325 3966346..3967326 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EL014_RS19330 3967909..3969135 - 1227 Protein_3743 helicase YjhR -
EL014_RS19335 3969213..3969512 + 300 WP_001332034.1 GNAT family N-acetyltransferase -
EL014_RS19340 3969889..3970146 + 258 WP_001054379.1 YjhX family toxin Toxin
EL014_RS19345 3970158..3970709 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
EL014_RS19350 3970761..3971507 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
EL014_RS19355 3971635..3971895 + 261 WP_000077645.1 hypothetical protein -
EL014_RS22765 3971933..3972049 + 117 Protein_3749 VOC family protein -
EL014_RS19360 3972294..3973415 + 1122 WP_000010833.1 M42 family metallopeptidase -
EL014_RS19365 3973412..3973690 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EL014_RS19370 3973702..3975015 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 3962384..3978930 16546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T286576 WP_001054379.1 NZ_LR134000:3969889-3970146 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT286576 WP_000123957.1 NZ_LR134000:3970158-3970709 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References