286568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2257318..2257844 Replicon chromosome
Accession NZ_LR134000
Organism Escherichia coli strain NCTC9066

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL014_RS11035 Protein ID WP_000323025.1
Coordinates 2257557..2257844 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL014_RS11030 Protein ID WP_000534858.1
Coordinates 2257318..2257557 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL014_RS10995 2252416..2252658 + 243 Protein_2124 DUF977 family protein -
EL014_RS11000 2252655..2253011 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL014_RS22710 2253622..2253909 + 288 Protein_2126 hypothetical protein -
EL014_RS11015 2254678..2255991 + 1314 WP_000589005.1 ISNCY family transposase -
EL014_RS11020 2256453..2256785 - 333 WP_001301033.1 protein FlxA -
EL014_RS11025 2256988..2257293 - 306 WP_001326990.1 hypothetical protein -
EL014_RS11030 2257318..2257557 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL014_RS11035 2257557..2257844 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL014_RS11040 2257916..2258071 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL014_RS11045 2258288..2258539 + 252 WP_000980994.1 hypothetical protein -
EL014_RS11050 2258606..2258884 + 279 WP_012304870.1 hypothetical protein -
EL014_RS11055 2258886..2259935 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL014_RS11060 2259949..2260701 + 753 WP_001047135.1 antitermination protein -
EL014_RS11065 2260979..2261068 - 90 WP_120795389.1 hypothetical protein -
EL014_RS11070 2261123..2261335 - 213 WP_000087756.1 cold shock-like protein CspF -
EL014_RS11075 2261636..2261851 + 216 WP_000066484.1 cold shock-like protein CspB -
EL014_RS22850 2262215..2262385 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL014_RS11080 2262605..2262820 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2237958..2274931 36973


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286568 WP_000323025.1 NZ_LR134000:2257557-2257844 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286568 WP_000534858.1 NZ_LR134000:2257318-2257557 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References