Detailed information of TA system TA028656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2335769..2336448
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: L0DWG8
• Locus tag: TVNIR_RS10735
• Protein ID: WP_015259055.1
• Coordinates: 2335769..2336188 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: L0DYA9
• Locus tag: TVNIR_RS10740
• Protein ID: WP_015259056.1
• Coordinates: 2336185..2336448 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS10720	2331734..2332963	+	1230	WP_015259052.1	hypothetical protein	-
TVNIR_RS10725	2333598..2334848	-	1251	WP_043739614.1	Fic family protein	-
TVNIR_RS10730	2334940..2335365	-	426	WP_211263113.1	hypothetical protein	-
TVNIR_RS10735	2335769..2336188	-	420	WP_015259055.1	type II toxin-antitoxin system VapC family toxin	Toxin
TVNIR_RS10740	2336185..2336448	-	264	WP_015259056.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TVNIR_RS10745	2337152..2338447	+	1296	WP_015259057.1	carboxypeptidase-like regulatory domain-containing protein	-
TVNIR_RS10750	2338983..2339342	+	360	WP_043739618.1	hypothetical protein	-
TVNIR_RS19075	2339786..2340229	-	444	WP_083499439.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• SpoVT-AbrB domain (11-42)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15501.67 Da
• Isoelectric Point: 6.2323

>T28656 WP_015259055.1 NC_019902:c2336188-2335769 [Thioalkalivibrio nitratireducens DSM 14787]
VTYLLDTNILIYLIKNRPPGIGQRIDELPDADELCMSFVTWAELLKGAERSTRKAEVVRRLEALARQVPVRYPAGPGICR
HYAEQATRLKDSGTPIGANDLWIACHALAEDATLVTHNTREFSRIGGLRIEDWAASTET

Nucleotide

• Length: 420 bp

>T28656 NC_019902:c2336188-2335769 [Thioalkalivibrio nitratireducens DSM 14787]
GTGACCTACCTGCTTGACACCAACATCCTGATCTACTTGATCAAGAATCGGCCGCCCGGCATTGGACAGCGCATCGATGA
GTTACCCGACGCCGATGAACTGTGCATGTCCTTTGTCACATGGGCCGAATTGCTCAAAGGGGCCGAGCGAAGCACGCGCA
AAGCCGAGGTCGTTCGCCGGCTTGAAGCCCTCGCGCGGCAGGTGCCGGTGCGTTACCCGGCCGGACCGGGCATCTGCCGT
CACTATGCAGAGCAGGCCACGCGTCTCAAAGACAGCGGTACCCCCATCGGCGCCAACGATCTATGGATCGCGTGCCACGC
GCTGGCGGAAGACGCCACTCTCGTAACCCACAATACCCGCGAGTTTAGCCGCATCGGCGGCCTGAGAATCGAGGACTGGG
CGGCATCCACCGAGACTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9619.85 Da
• Isoelectric Point: 4.7672

>AT28656 WP_015259056.1 NC_019902:c2336448-2336185 [Thioalkalivibrio nitratireducens DSM 14787]
MGTLTTRVFNNGNSQAVRIPAEFRLDTDRVSISRKEDGDLVIHPLPAQRGTALMRTLQALSEVDDAFVAALEAEQRSSLP
VQEREVL

Nucleotide

• Length: 264 bp

>AT28656 NC_019902:c2336448-2336185 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGGGACACTGACCACCCGCGTCTTCAACAACGGCAACAGTCAGGCGGTTCGCATTCCCGCCGAGTTCCGGCTGGACAC
CGATCGTGTGAGCATATCCCGCAAAGAGGACGGCGATCTCGTGATTCATCCACTACCCGCGCAGCGCGGCACGGCACTGA
TGCGGACGCTACAGGCGCTGAGCGAGGTCGATGACGCCTTCGTTGCCGCGCTGGAGGCCGAACAGCGTTCTTCCTTGCCG
GTGCAGGAGCGTGAGGTCCTGTGA

Structures

Toxin

• AlphaFold DB: L0DWG8

Antitoxin

• AlphaFold DB: L0DYA9