Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2948148..2948771 Replicon chromosome
Accession NZ_LR133996
Organism Shimwellia blattae strain NCTC10965

Toxin (Protein)


Gene name Hha Uniprot ID I2BBN0
Locus tag EL017_RS14200 Protein ID WP_002438965.1
Coordinates 2948553..2948771 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID I2BBM9
Locus tag EL017_RS14195 Protein ID WP_002438967.1
Coordinates 2948148..2948528 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL017_RS14185 2943266..2944441 + 1176 WP_002438970.1 efflux RND transporter periplasmic adaptor subunit -
EL017_RS14190 2944464..2947619 + 3156 WP_002438968.1 multidrug efflux RND transporter permease subunit -
EL017_RS14195 2948148..2948528 + 381 WP_002438967.1 Hha toxicity modulator TomB Antitoxin
EL017_RS14200 2948553..2948771 + 219 WP_002438965.1 hemolysin expression modulator Hha Toxin
EL017_RS14205 2949164..2949637 + 474 WP_002438964.1 YlaC family protein -
EL017_RS14215 2949846..2950280 + 435 WP_164558553.1 MGMT family protein -
EL017_RS14220 2950332..2950862 - 531 WP_002438961.1 YbaY family lipoprotein -
EL017_RS14225 2951070..2951933 + 864 WP_002438960.1 acyl-CoA thioesterase II -
EL017_RS14230 2951982..2953262 - 1281 WP_002438958.1 ammonium transporter AmtB -
EL017_RS14235 2953293..2953631 - 339 WP_002438956.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8600.97 Da        Isoelectric Point: 8.9008

>T286557 WP_002438965.1 NZ_LR133996:2948553-2948771 [Shimwellia blattae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDTELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14653.43 Da        Isoelectric Point: 4.7334

>AT286557 WP_002438967.1 NZ_LR133996:2948148-2948528 [Shimwellia blattae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLGETNRGWVNDPTSAINLQLNDLIEHIATFALNYKIKYDDDSKLIEQIDEYL
DDTFTLFSNYGIDAKDLQKWQKSGNRLFRCFVNASRANPVSLSLEK

Download         Length: 381 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2BBN0

Antitoxin

Source ID Structure
AlphaFold DB I2BBM9

References