Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1891219..1891976 Replicon chromosome
Accession NZ_LR133996
Organism Shimwellia blattae strain NCTC10965

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EL017_RS09010 Protein ID WP_002443842.1
Coordinates 1891494..1891976 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID I2B8R4
Locus tag EL017_RS09005 Protein ID WP_002443844.1
Coordinates 1891219..1891503 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL017_RS08990 1887909..1888349 + 441 WP_002443850.1 hypothetical protein -
EL017_RS08995 1888369..1889460 - 1092 WP_174270567.1 MBL fold metallo-hydrolase -
EL017_RS09000 1889626..1891140 + 1515 WP_002443846.1 PLP-dependent aminotransferase family protein -
EL017_RS09005 1891219..1891503 + 285 WP_002443844.1 DUF1778 domain-containing protein Antitoxin
EL017_RS09010 1891494..1891976 + 483 WP_002443842.1 GNAT family N-acetyltransferase Toxin
EL017_RS09015 1892249..1893593 + 1345 Protein_1729 carbohydrate porin -
EL017_RS09020 1893629..1894087 - 459 WP_002443838.1 multidrug/biocide efflux PACE transporter -
EL017_RS09025 1894185..1895063 + 879 WP_002443836.1 LysR family transcriptional regulator -
EL017_RS09030 1895117..1896043 - 927 WP_002443834.1 omptin family outer membrane protease -
EL017_RS09035 1896318..1896802 - 485 Protein_1733 [NiFe]-hydrogenase assembly chaperone HybE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(34-149)

Antitoxin

Vibrio phage ICP1, Orf50

(13-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17869.73 Da        Isoelectric Point: 8.2935

>T286554 WP_002443842.1 NZ_LR133996:1891494-1891976 [Shimwellia blattae]
MEINVTAPALLTEDHILQPFDCGNDILSDWLRRRAIKNQHLNASRTFVICLEGTKRVVGYYSIATGSVSHIDLGRSLRKN
MPDPVPVVLLGRLAVDVCTQGNSFGKWMLNDAVMRVSNLADQVGIKAIMVHAINDEAKAFYEHFGFVQSPLTPRTLFFKI

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10984.36 Da        Isoelectric Point: 4.9059

>AT286554 WP_002443844.1 NZ_LR133996:1891219-1891503 [Shimwellia blattae]
MHTTIRKATRDKQINIRATEEERAVIDYAASLLNKNRTDFIIEQAVSEAQNIILDQRVFALDDARYQAFIEQLEGPVQNE
EGRQRLLDVKPEWK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2B8R4

References