Detailed information of TA system TA028655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2310622..2311280
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: L0DY11
• Locus tag: TVNIR_RS10645
• Protein ID: WP_015259039.1
• Coordinates: 2310622..2311026 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L0DWF9
• Locus tag: TVNIR_RS10650
• Protein ID: WP_015259040.1
• Coordinates: 2311026..2311280 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS10630	2306960..2308132	-	1173	WP_043739607.1	Fic family protein	-
TVNIR_RS10635	2308558..2310302	+	1745	Protein_2142	IS1182 family transposase	-
TVNIR_RS10645	2310622..2311026	-	405	WP_015259039.1	type II toxin-antitoxin system VapC family toxin	Toxin
TVNIR_RS10650	2311026..2311280	-	255	WP_015259040.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TVNIR_RS10655	2311401..2311691	-	291	WP_043740560.1	nucleotidyltransferase family protein	-
TVNIR_RS10665	2312055..2312309	+	255	WP_015259042.1	type II toxin-antitoxin system RelE/ParE family toxin	-
TVNIR_RS10670	2312538..2312834	-	297	WP_043739610.1	type II toxin-antitoxin system RelE/ParE family toxin	-
TVNIR_RS20010	2312822..2313007	-	186	WP_015259044.1	hypothetical protein	-
TVNIR_RS10680	2313231..2314370	-	1140	WP_015259045.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14648.54 Da
• Isoelectric Point: 5.1784

>T28655 WP_015259039.1 NC_019902:c2311026-2310622 [Thioalkalivibrio nitratireducens DSM 14787]
MVIDTSALVAILQDEPERHAFNEAIEAAESRLLSVANWVETSIVIEVRYGTAGLHLLDRFLDRAAIDCVPVDLRQAKEAR
RAFSQYGKGRHPAGLNYGDCFAYALARTNGQPLLFKGDDFARTDIAPSIGSAAQ

Nucleotide

• Length: 405 bp

>T28655 NC_019902:c2311026-2310622 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGTCATCGATACATCGGCGCTGGTTGCCATTCTCCAGGACGAGCCGGAACGGCACGCTTTCAACGAAGCCATCGAGGC
TGCGGAGTCGCGCTTGCTTTCGGTAGCCAACTGGGTCGAGACGTCCATCGTGATCGAGGTGCGCTACGGCACGGCGGGGC
TGCATCTGCTCGACCGTTTCCTCGATCGCGCGGCGATCGACTGCGTGCCGGTGGATCTTCGGCAAGCAAAGGAGGCGCGC
CGCGCCTTCAGCCAGTACGGCAAGGGGCGACACCCGGCCGGCCTGAACTATGGTGACTGTTTCGCTTATGCGCTGGCGCG
CACGAATGGACAGCCGCTGCTCTTCAAGGGTGACGATTTCGCCCGCACGGACATCGCGCCCAGCATTGGCTCAGCCGCCC
AGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9411.58 Da
• Isoelectric Point: 5.2168

>AT28655 WP_015259040.1 NC_019902:c2311280-2311026 [Thioalkalivibrio nitratireducens DSM 14787]
MALNIRNPEADRLAAELAQATGETKTEAVIQAMRDRLDRVRRERGGTRLADELDEIARACAALPVRDRRSAEEILGYDEH
GLPR

Nucleotide

• Length: 255 bp

>AT28655 NC_019902:c2311280-2311026 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGCGCTGAATATCCGAAATCCAGAAGCGGATCGGCTGGCAGCAGAGCTGGCCCAGGCCACGGGCGAAACCAAAACCGA
GGCGGTGATTCAAGCGATGCGGGATCGCCTGGACCGGGTGCGCCGTGAGCGTGGGGGAACGCGGCTGGCGGACGAGCTGG
ACGAGATCGCGCGTGCCTGCGCGGCATTGCCGGTTCGCGATCGCCGCAGTGCGGAGGAGATCCTCGGTTACGACGAGCAT
GGTCTCCCGCGCTGA

Structures

Toxin

• AlphaFold DB: L0DY11

Antitoxin

• AlphaFold DB: L0DWF9