Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1491080..1491606 Replicon chromosome
Accession NZ_LR133996
Organism Shimwellia blattae strain NCTC10965

Toxin (Protein)


Gene name relE Uniprot ID I2B7N1
Locus tag EL017_RS07030 Protein ID WP_002439942.1
Coordinates 1491319..1491606 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I2B7N0
Locus tag EL017_RS07025 Protein ID WP_002439941.1
Coordinates 1491080..1491319 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL017_RS07005 1486430..1487218 + 789 WP_002439937.1 hydroxyethylthiazole kinase -
EL017_RS07010 1487221..1488024 + 804 WP_034920040.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
EL017_RS07015 1488181..1489233 + 1053 WP_002439939.1 class I fructose-bisphosphate aldolase -
EL017_RS07020 1489458..1490828 - 1371 WP_002439940.1 tRNA 5-hydroxyuridine modification protein YegQ -
EL017_RS07025 1491080..1491319 + 240 WP_002439941.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL017_RS07030 1491319..1491606 + 288 WP_002439942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL017_RS07035 1491683..1492408 - 726 WP_002439943.1 two-component system response regulator BaeR -
EL017_RS07040 1492405..1493799 - 1395 WP_002439944.1 two-component system sensor histidine kinase BaeS -
EL017_RS07045 1493799..1495214 - 1416 WP_002439945.1 multidrug transporter subunit MdtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11183.14 Da        Isoelectric Point: 10.2262

>T286548 WP_002439942.1 NZ_LR133996:1491319-1491606 [Shimwellia blattae]
MAYFLDFDERALKEWRKLGSTVREQFKKKLAEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDAQVVVFVISVGK
RERPEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9127.54 Da        Isoelectric Point: 4.5230

>AT286548 WP_002439941.1 NZ_LR133996:1491080-1491319 [Shimwellia blattae]
MGSINLRIDDELKARSYAALEKMGITPSEALRLMLEYIADNERLPFRQTLLSDEDAELVEIIKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2B7N1

Antitoxin

Source ID Structure
AlphaFold DB I2B7N0

References