Detailed information of TA system TA286539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4695734..4697415
• Replicon: chromosome
• Accession: NZ_LR133964
• Organism: Klebsiella pneumoniae strain NCTC11359

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: EL047_RS23360
• Protein ID: WP_004146663.1
• Coordinates: 4695734..4696651 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: EL047_RS23365
• Protein ID: WP_122051607.1
• Coordinates: 4696657..4697415 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL047_RS23340	4691039..4692559	+	1521	WP_122051606.1	sugar ABC transporter ATP-binding protein	-
EL047_RS23345	4692556..4693555	+	1000	Protein_4477	ribose ABC transporter permease	-
EL047_RS23350	4693586..4694527	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
EL047_RS23355	4694602..4695609	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
EL047_RS23360	4695734..4696651	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL047_RS23365	4696657..4697415	-	759	WP_122051607.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
EL047_RS23370	4697501..4698229	-	729	WP_023288135.1	response regulator transcription factor	-
EL047_RS23375	4698502..4700649	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
EL047_RS25865	4700646..4700789	-	144	WP_162992563.1	hypothetical protein	-
EL047_RS23380	4700995..4701681	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (2-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T286539 WP_004146663.1 NZ_LR133964:c4696651-4695734 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28576.98 Da
• Isoelectric Point: 10.0870

>AT286539 WP_122051607.1 NZ_LR133964:c4697415-4696657 [Klebsiella pneumoniae]
MVTKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1