Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1323341..1323934 Replicon chromosome
Accession NC_019902
Organism Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag TVNIR_RS19705 Protein ID WP_043739463.1
Coordinates 1323635..1323934 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag TVNIR_RS19700 Protein ID WP_058933125.1
Coordinates 1323341..1323634 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TVNIR_RS06325 1318989..1319951 - 963 WP_157092340.1 iron ABC transporter permease -
TVNIR_RS06330 1319990..1320889 - 900 WP_015258166.1 cobalamin-binding protein -
TVNIR_RS06335 1321217..1322623 + 1407 WP_043739461.1 glutamate--tRNA ligase -
TVNIR_RS06345 1322762..1322980 + 219 WP_015258168.1 hypothetical protein -
TVNIR_RS19700 1323341..1323634 - 294 WP_058933125.1 putative addiction module antidote protein Antitoxin
TVNIR_RS19705 1323635..1323934 - 300 WP_043739463.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TVNIR_RS06365 1324410..1325432 - 1023 WP_052316621.1 hypothetical protein -
TVNIR_RS19710 1325914..1326120 + 207 WP_211263153.1 copper resistance protein NlpE N-terminal domain-containing protein -
TVNIR_RS06370 1326056..1327747 - 1692 WP_015258170.1 glutamine--tRNA ligase/YqeY domain fusion protein -
TVNIR_RS06375 1327884..1328522 - 639 WP_015258171.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-93)

Antitoxin

Uncharacterized protein HI1420

(2-96)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11289.93 Da        Isoelectric Point: 9.5482

>T28653 WP_043739463.1 NC_019902:c1323934-1323635 [Thioalkalivibrio nitratireducens DSM 14787]
MLEVYKTEEFARWFRKLRDRQAKARIQARIDRLEQGNFGDVESVGDGIHELRIFCGPGYRVYFTQLSSVIVILLTGGDKG
SQSKDIAKAKELAQKLEAQ

Download         Length: 300 bp

>T28653 NC_019902:c1323934-1323635 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCTGGAAGTCTATAAGACAGAAGAGTTCGCCCGCTGGTTCAGGAAGCTTCGGGACCGTCAGGCCAAGGCGCGAATTCA
AGCTCGAATTGACCGACTTGAACAGGGTAATTTTGGCGATGTCGAGTCGGTTGGAGACGGTATCCATGAGCTACGCATAT
TCTGTGGCCCCGGGTATAGAGTCTACTTCACCCAACTCTCTTCAGTTATCGTGATTCTTCTAACGGGCGGCGATAAAGGC
TCCCAAAGCAAAGATATCGCGAAAGCGAAAGAATTGGCCCAGAAATTGGAGGCGCAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10576.01 Da        Isoelectric Point: 4.6258

>AT28653 WP_058933125.1 NC_019902:c1323634-1323341 [Thioalkalivibrio nitratireducens DSM 14787]
MTVKLSRWDSAEYLTTEEDIQAYLEAVLEEGGDDPAYMIHALGVIARAKNMSQLAREAGISREGLYKALSEEGNPTFATV
AKIARALGLQIKFQTAA

Download         Length: 294 bp

>AT28653 NC_019902:c1323634-1323341 [Thioalkalivibrio nitratireducens DSM 14787]
ATGACCGTTAAGCTAAGTCGTTGGGATTCGGCTGAATATTTGACAACAGAGGAAGATATCCAAGCCTACCTGGAAGCTGT
CTTAGAAGAAGGGGGTGATGATCCTGCTTATATGATCCATGCTCTCGGAGTGATCGCGCGAGCGAAGAACATGAGCCAGC
TAGCCAGGGAAGCTGGCATTTCCAGAGAGGGGCTTTATAAAGCCCTATCTGAAGAAGGGAACCCCACTTTTGCAACAGTG
GCCAAAATCGCCAGAGCGTTGGGGTTGCAAATCAAGTTTCAAACGGCTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References