Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5127048..5127705 Replicon chromosome
Accession NZ_LR133932
Organism Klebsiella oxytoca strain NCTC11356

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag EL063_RS24400 Protein ID WP_004105559.1
Coordinates 5127048..5127458 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag EL063_RS24405 Protein ID WP_004105561.1
Coordinates 5127439..5127705 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL063_RS24380 5123025..5124758 - 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -
EL063_RS24385 5124764..5125477 - 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL063_RS24390 5125500..5126396 - 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
EL063_RS24395 5126518..5127039 + 522 WP_004105557.1 flavodoxin FldB -
EL063_RS24400 5127048..5127458 - 411 WP_004105559.1 protein YgfX Toxin
EL063_RS24405 5127439..5127705 - 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
EL063_RS24410 5127949..5128932 + 984 WP_004115279.1 tRNA-modifying protein YgfZ -
EL063_RS24415 5129061..5129720 - 660 WP_064344096.1 hemolysin III family protein -
EL063_RS24420 5129882..5130193 - 312 WP_126489545.1 N(4)-acetylcytidine aminohydrolase -
EL063_RS24425 5130244..5130972 + 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
EL063_RS24430 5131093..5132526 + 1434 WP_126489546.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T286525 WP_004105559.1 NZ_LR133932:c5127458-5127048 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT286525 WP_004105561.1 NZ_LR133932:c5127705-5127439 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References