286520

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1607489..1608108 Replicon chromosome
Accession NZ_LR133932
Organism Klebsiella oxytoca strain NCTC11356

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag EL063_RS07625 Protein ID WP_004099646.1
Coordinates 1607489..1607707 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag EL063_RS07630 Protein ID WP_004099648.1
Coordinates 1607734..1608108 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL063_RS07595 1603525..1603788 + 264 WP_004099638.1 type B 50S ribosomal protein L31 -
EL063_RS07600 1603788..1603928 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL063_RS07605 1603925..1604623 - 699 WP_004099639.1 GNAT family N-acetyltransferase -
EL063_RS07610 1604726..1606180 + 1455 WP_126488646.1 PLP-dependent aminotransferase family protein -
EL063_RS07615 1606155..1606625 - 471 WP_004099643.1 YlaC family protein -
EL063_RS07620 1606762..1607328 - 567 WP_023320460.1 maltose O-acetyltransferase -
EL063_RS07625 1607489..1607707 - 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
EL063_RS07630 1607734..1608108 - 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
EL063_RS07635 1608590..1611736 - 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit -
EL063_RS07640 1611759..1612952 - 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T286520 WP_004099646.1 NZ_LR133932:c1607707-1607489 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT286520 WP_004099648.1 NZ_LR133932:c1608108-1607734 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References