Detailed information of TA system TA028652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1088587..1089694
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: -
• Uniprot ID: L0DUY6
• Locus tag: TVNIR_RS05315
• Protein ID: WP_015257960.1
• Coordinates: 1088587..1089333 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: L0DUX6
• Locus tag: TVNIR_RS05320
• Protein ID: WP_006748086.1
• Coordinates: 1089335..1089694 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS05290	1084557..1085408	-	852	WP_015257956.1	hypothetical protein	-
TVNIR_RS05295	1085492..1086502	-	1011	WP_211263149.1	NAD-dependent epimerase/dehydratase family protein	-
TVNIR_RS05300	1086741..1087481	+	741	WP_015257958.1	hypothetical protein	-
TVNIR_RS18850	1087746..1087943	+	198	WP_083499365.1	type II toxin-antitoxin system HicA family toxin	-
TVNIR_RS18855	1087940..1088179	+	240	WP_083499366.1	hypothetical protein	-
TVNIR_RS20160	1088317..1088541	-	225	WP_015257959.1	transposase	-
TVNIR_RS05315	1088587..1089333	-	747	WP_015257960.1	RES family NAD+ phosphorylase	Toxin
TVNIR_RS05320	1089335..1089694	-	360	WP_006748086.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
TVNIR_RS05325	1089995..1090441	+	447	Protein_1090	ATP-binding domain-containing protein	-
TVNIR_RS05330	1090484..1090900	-	417	WP_043739396.1	PIN domain-containing protein	-
TVNIR_RS05335	1090897..1091166	-	270	WP_015257962.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
TVNIR_RS05340	1091256..1091480	+	225	WP_211263150.1	DUF86 domain-containing protein	-
TVNIR_RS05345	1091715..1091951	+	237	WP_015257964.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
TVNIR_RS05350	1091948..1092322	+	375	WP_015257965.1	type II toxin-antitoxin system VapC family toxin	-
TVNIR_RS05355	1092525..1093085	+	561	WP_043739400.1	Uma2 family endonuclease	-
TVNIR_RS05360	1093290..1093532	+	243	WP_015257967.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
TVNIR_RS05365	1093529..1093792	+	264	WP_015257968.1	Txe/YoeB family addiction module toxin	-
TVNIR_RS05370	1093868..1094299	-	432	WP_052316617.1	hypothetical protein	-
TVNIR_RS18860	1094321..1094590	+	270	WP_083499367.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1071337..1095380	24043

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-208)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-117)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28282.27 Da
• Isoelectric Point: 8.8927

>T28652 WP_015257960.1 NC_019902:c1089333-1088587 [Thioalkalivibrio nitratireducens DSM 14787]
MPDWAARIEAAPRVALKGEVLRLVESQEQVATNQLVSSLERQAVLEEMLESTKPPLRPGTERLHYLLATPFRYPPLRHGS
RFGRRHEPSLFYGALGERTVLAEAAYYRFVFWYGMATPPLRKLDTQHTLFAARYQGRDGILLHQPPFEDSTPLLRHPADY
SATQALGTAMREAGIDLFEYRSARDTEAGLNLALYHPRPFTRKTPTRQDAWLCQLTAEHVRFRKTGDGTLQDFALEQFLH
CGRLPLPA

Nucleotide

• Length: 747 bp

>T28652 NC_019902:c1089333-1088587 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCCCGATTGGGCGGCACGCATCGAAGCCGCACCCCGGGTGGCCCTGAAAGGAGAAGTCCTGCGCCTCGTCGAGAGCCA
GGAGCAGGTCGCCACCAATCAACTGGTGTCCTCGCTGGAACGCCAGGCGGTGTTGGAAGAGATGCTGGAATCGACCAAAC
CGCCGCTGCGTCCGGGCACCGAGCGGCTGCATTACCTGCTGGCGACGCCGTTTCGCTATCCGCCGCTACGCCATGGCTCG
CGCTTCGGTCGGCGCCATGAACCGAGCCTGTTCTACGGGGCGCTGGGCGAACGCACGGTACTGGCGGAAGCCGCCTACTA
CCGGTTCGTCTTCTGGTACGGGATGGCCACCCCGCCGCTGCGCAAGCTCGACACCCAGCACACGCTGTTTGCCGCCCGGT
ACCAGGGGCGTGACGGCATCCTGCTCCATCAGCCTCCGTTCGAGGACAGCACCCCCCTGCTCCGCCATCCCGCCGACTAC
AGCGCCACCCAGGCATTGGGCACCGCGATGCGCGAGGCCGGCATCGACCTGTTCGAGTACCGCTCGGCGCGGGATACGGA
GGCGGGCCTCAACCTTGCGCTCTACCATCCGCGCCCGTTCACTCGAAAGACACCCACCCGGCAGGATGCCTGGCTCTGCC
AGTTGACCGCCGAGCACGTGCGCTTCCGGAAAACCGGCGACGGTACGCTGCAGGATTTCGCGCTCGAGCAGTTCCTGCAC
TGCGGCCGCCTGCCGCTGCCGGCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 12578.53 Da
• Isoelectric Point: 8.9978

>AT28652 WP_006748086.1 NC_019902:c1089694-1089335 [Thioalkalivibrio nitratireducens DSM 14787]
MGSVTALAPQRAEVLREALVNAGKALGLTQAELGAVIGRGRTDISRGNVDPDSKPGELALLLIRCYRALYVLTGGDAGAM
KHWMHTPNHHTGGVPAEQIRSVQGLVGVLEYLDAIRGKI

Nucleotide

• Length: 360 bp

>AT28652 NC_019902:c1089694-1089335 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGGTAGTGTTACGGCTCTGGCTCCTCAGCGCGCGGAGGTCCTGCGCGAGGCGCTGGTCAATGCCGGCAAGGCATTGGG
CCTGACCCAGGCGGAACTGGGCGCGGTGATCGGGCGCGGGCGCACGGACATCAGCAGGGGCAACGTCGATCCGGACAGCA
AGCCGGGAGAACTGGCGTTGCTGCTGATCCGCTGCTATCGCGCCCTGTACGTGCTGACCGGAGGGGACGCCGGTGCGATG
AAGCACTGGATGCACACGCCCAACCACCACACCGGGGGCGTGCCGGCCGAGCAGATCCGCTCGGTGCAGGGCCTGGTGGG
CGTGCTCGAATACCTCGACGCGATCCGGGGCAAGATCTGA

Structures

Toxin

• AlphaFold DB: L0DUY6

Antitoxin

• AlphaFold DB: L0DUX6