Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 1376102..1376921 Replicon chromosome
Accession NZ_LR133932
Organism Klebsiella oxytoca strain NCTC11356

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag EL063_RS06520 Protein ID WP_004110819.1
Coordinates 1376102..1376359 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag EL063_RS06525 Protein ID WP_126488543.1
Coordinates 1376370..1376921 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL063_RS06505 1371873..1372649 - 777 WP_017146569.1 Uxu operon transcriptional regulator -
EL063_RS06510 1372785..1374260 - 1476 WP_126488541.1 fructuronate reductase -
EL063_RS06515 1374335..1375519 - 1185 WP_004099225.1 mannonate dehydratase -
EL063_RS06520 1376102..1376359 + 258 WP_004110819.1 YjhX family toxin Toxin
EL063_RS06525 1376370..1376921 + 552 WP_126488543.1 N-acetyltransferase Antitoxin
EL063_RS06530 1376939..1378567 + 1629 WP_126489686.1 SAM-dependent methyltransferase -
EL063_RS06535 1378613..1379776 - 1164 WP_024273763.1 MFS transporter -
EL063_RS06540 1379794..1381071 - 1278 WP_024273764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1381203..1382081 878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(17-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T286519 WP_004110819.1 NZ_LR133932:1376102-1376359 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20133.09 Da        Isoelectric Point: 6.7176

>AT286519 WP_126488543.1 NZ_LR133932:1376370-1376921 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGITGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References