Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2075065..2075594 Replicon chromosome
Accession NZ_LR133917
Organism Staphylococcus aureus strain NCTC8317

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ45_RS10710 Protein ID WP_000621175.1
Coordinates 2075065..2075427 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag ELZ45_RS10715 Protein ID WP_000948331.1
Coordinates 2075424..2075594 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ45_RS10685 2072052..2072822 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
ELZ45_RS10690 2072797..2073276 - 480 WP_001190830.1 anti-sigma B factor RsbW -
ELZ45_RS10695 2073278..2073595 - 318 WP_126497024.1 anti-sigma factor antagonist -
ELZ45_RS10700 2073714..2074715 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ELZ45_RS10710 2075065..2075427 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ45_RS10715 2075424..2075594 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ45_RS10720 2075679..2076827 - 1149 WP_001281145.1 alanine racemase -
ELZ45_RS10725 2076893..2077252 - 360 WP_000581200.1 holo-ACP synthase -
ELZ45_RS10730 2077256..2077747 - 492 WP_001205910.1 PH domain-containing protein -
ELZ45_RS10735 2077734..2079317 - 1584 WP_001294626.1 PH domain-containing protein -
ELZ45_RS10740 2079310..2079789 - 480 WP_001287088.1 hypothetical protein -
ELZ45_RS10745 2079998..2080558 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286512 WP_000621175.1 NZ_LR133917:c2075427-2075065 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286512 WP_000948331.1 NZ_LR133917:c2075594-2075424 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References