Detailed information of TA system TA028651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 694208..694887
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: L0DS91
• Locus tag: TVNIR_RS03580
• Protein ID: WP_015257611.1
• Coordinates: 694208..694642 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: TVNIR_RS03585
• Protein ID: WP_043739242.1
• Coordinates: 694642..694887 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS03545	689597..690370	+	774	WP_015257605.1	YdcF family protein	-
TVNIR_RS03550	690461..690901	-	441	WP_015257606.1	putative toxin-antitoxin system toxin component, PIN family	-
TVNIR_RS03555	690883..691104	-	222	WP_006749192.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
TVNIR_RS03560	691510..691719	+	210	WP_015257607.1	type II toxin-antitoxin system HicB family antitoxin	-
TVNIR_RS03565	691765..691950	+	186	WP_211263175.1	type II toxin-antitoxin system HicA family toxin	-
TVNIR_RS03570	692204..693097	+	894	WP_015257610.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
TVNIR_RS03575	693624..693911	+	288	WP_006749202.1	GIY-YIG nuclease family protein	-
TVNIR_RS03580	694208..694642	-	435	WP_015257611.1	PIN domain-containing protein	Toxin
TVNIR_RS03585	694642..694887	-	246	WP_043739242.1	hypothetical protein	Antitoxin
TVNIR_RS03590	695839..697095	+	1257	WP_015257613.1	LegC family aminotransferase	-
TVNIR_RS03595	697787..698974	+	1188	WP_015257614.1	UDP-N-acetylglucosamine 4,6-dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	691618..710303	18685
	-	flank	IS/Tn	-	-	699226..699387	161

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16418.66 Da
• Isoelectric Point: 8.1438

>T28651 WP_015257611.1 NC_019902:c694642-694208 [Thioalkalivibrio nitratireducens DSM 14787]
MRALLDINVVIALLDAAHTLHRSATNWLAQEIQHGWASCPITENGVVRIMSQPTYPNTQPLQQVALRVREAQQNSDHRFW
PDDISLTASDLLNWPQLLGHRQITDAYLLAIAARNNGRLVTFDQRIRYDAVKGAEQRHLHVIRT

Nucleotide

• Length: 435 bp

>T28651 NC_019902:c694642-694208 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCGCGCGCTTCTGGATATCAACGTCGTCATCGCGCTCCTCGACGCCGCCCACACCCTGCATCGATCCGCCACAAACTG
GCTGGCACAGGAAATACAACACGGCTGGGCATCCTGCCCGATCACGGAAAACGGCGTGGTGCGGATCATGTCGCAACCGA
CGTACCCCAACACCCAGCCCCTACAGCAGGTGGCCCTACGGGTTCGCGAAGCCCAGCAAAACTCAGATCACCGATTCTGG
CCAGACGACATCAGCCTCACGGCAAGCGATCTTCTGAACTGGCCACAACTCCTCGGCCACCGACAGATCACCGACGCGTA
CCTGCTGGCCATCGCAGCGCGCAACAACGGGCGCCTCGTTACGTTCGACCAGCGGATCCGATACGACGCGGTGAAGGGTG
CCGAGCAGCGACACCTGCACGTCATCCGCACTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8861.91 Da
• Isoelectric Point: 5.1369

>AT28651 WP_043739242.1 NC_019902:c694887-694642 [Thioalkalivibrio nitratireducens DSM 14787]
MRTTIDIEDDVLEAAKEIAQRERTSAGRVVSRLLRAALTQPATPQGEPSTRGVGGFRPFASPSARIVTNERVEQLRDEEG
V

Nucleotide

• Length: 246 bp

>AT28651 NC_019902:c694887-694642 [Thioalkalivibrio nitratireducens DSM 14787]
ATGAGAACGACGATCGACATCGAAGATGACGTCCTCGAGGCCGCCAAGGAAATCGCGCAACGAGAGCGCACCTCGGCGGG
CCGAGTGGTTTCGCGCCTGCTACGTGCCGCACTGACGCAACCGGCCACACCGCAGGGCGAGCCTTCCACCCGAGGCGTCG
GCGGCTTCCGTCCCTTCGCCTCTCCATCGGCCCGCATCGTCACCAACGAGAGGGTCGAGCAGTTACGGGACGAAGAAGGG
GTCTGA

Structures

Toxin

• AlphaFold DB: L0DS91