286505

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 59735..60872 Replicon plasmid 2
Accession NZ_LR132068
Organism Enterococcus faecium isolate E0139

Toxin (Protein)


Gene name zeta Uniprot ID D1MAU9
Locus tag ELZ42_RS12890 Protein ID WP_002333464.1
Coordinates 60009..60872 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag ELZ42_RS12885 Protein ID WP_000301765.1
Coordinates 59735..60007 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ42_RS12840 55238..56836 + 1599 WP_126340550.1 type IA DNA topoisomerase -
ELZ42_RS12845 56962..57126 + 165 WP_002935077.1 peptide-binding protein -
ELZ42_RS12850 57147..57242 + 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
ELZ42_RS12855 57367..58104 + 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
ELZ42_RS12865 58250..58534 + 285 WP_078100292.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
ELZ42_RS12870 58679..58945 + 267 WP_126340551.1 AAA family ATPase -
ELZ42_RS12875 58949..59404 + 456 Protein_63 ParA family protein -
ELZ42_RS12880 59509..59718 + 210 WP_000527317.1 peptide-binding protein -
ELZ42_RS12885 59735..60007 + 273 WP_000301765.1 antitoxin Antitoxin
ELZ42_RS12890 60009..60872 + 864 WP_002333464.1 zeta toxin family protein Toxin
ELZ42_RS12895 61313..61630 + 318 WP_002333463.1 hypothetical protein -
ELZ42_RS12900 62164..62661 + 498 WP_002325587.1 hypothetical protein -
ELZ42_RS12905 62695..62967 + 273 WP_002325586.1 hypothetical protein -
ELZ42_RS12910 62997..63677 - 681 WP_002332989.1 IS6 family transposase -
ELZ42_RS12920 64106..64528 + 423 WP_002307506.1 cupin domain-containing protein -
ELZ42_RS12925 64612..65265 + 654 WP_002307505.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid vat(D) / erm(B) / VanHAX - 1..141895 141895
- inside IScluster/Tn vat(D) / erm(B) - 53015..67642 14627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32370.87 Da        Isoelectric Point: 6.6610

>T286505 WP_002333464.1 NZ_LR132068:60009-60872 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT286505 WP_000301765.1 NZ_LR132068:59735-60007 [Enterococcus faecium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1MAU9

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References