286504

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 470465..471036 Replicon chromosome
Accession NZ_LR132067
Organism Enterococcus faecium isolate E0139

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ42_RS02425 Protein ID WP_002328559.1
Coordinates 470695..471036 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag ELZ42_RS02420 Protein ID WP_002323011.1
Coordinates 470465..470695 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ42_RS02375 465583..466911 + 1329 WP_002327663.1 FAD-containing oxidoreductase -
ELZ42_RS02380 466933..467559 + 627 WP_002286816.1 cysteine hydrolase -
ELZ42_RS02385 467742..468323 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
ELZ42_RS02405 469055..469630 + 576 WP_002327664.1 SOS response-associated peptidase family protein -
ELZ42_RS02410 469831..470205 - 375 WP_158225605.1 hypothetical protein -
ELZ42_RS02420 470465..470695 + 231 WP_002323011.1 hypothetical protein Antitoxin
ELZ42_RS02425 470695..471036 + 342 WP_002328559.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ42_RS02430 471855..473017 + 1163 WP_086956687.1 IS3 family transposase -
ELZ42_RS02440 473148..474332 + 1185 Protein_448 hypothetical protein -
ELZ42_RS02445 474332..475645 + 1314 WP_002328556.1 LPXTG-protein cell wall anchor protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13278.70 Da        Isoelectric Point: 10.1461

>T286504 WP_002328559.1 NZ_LR132067:470695-471036 [Enterococcus faecium]
VSGERIYIPKKGDIVWIYFDPSLGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT286504 WP_002323011.1 NZ_LR132067:470465-470695 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References