Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 1852788..1853473 Replicon chromosome
Accession NZ_LR131273
Organism Tsukamurella paurometabola strain NCTC10741

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ELY19_RS09280 Protein ID WP_164711568.1
Coordinates 1852788..1853186 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ELY19_RS09285 Protein ID WP_126195936.1
Coordinates 1853192..1853473 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELY19_RS09245 1848692..1849516 - 825 WP_126195929.1 Rv3717 family N-acetylmuramoyl-L-alanine amidase -
ELY19_RS09250 1849610..1849918 + 309 WP_126195930.1 YbaB/EbfC family nucleoid-associated protein -
ELY19_RS09255 1849929..1850582 + 654 WP_126195931.1 recombination mediator RecR -
ELY19_RS09260 1850586..1851134 + 549 WP_126195932.1 hypothetical protein -
ELY19_RS09265 1851194..1851763 + 570 WP_126198767.1 DinB family protein -
ELY19_RS09270 1851773..1852261 + 489 WP_126195933.1 SRPBCC family protein -
ELY19_RS09275 1852263..1852787 + 525 WP_126195934.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
ELY19_RS09280 1852788..1853186 - 399 WP_164711568.1 type II toxin-antitoxin system VapC family toxin Toxin
ELY19_RS09285 1853192..1853473 - 282 WP_126195936.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELY19_RS09290 1853835..1854542 - 708 WP_126198768.1 glutamine amidotransferase -
ELY19_RS09295 1854569..1855816 - 1248 WP_126195937.1 Mur ligase family protein -
ELY19_RS09300 1855855..1856601 + 747 WP_126195938.1 class I SAM-dependent methyltransferase -
ELY19_RS09305 1856488..1857483 - 996 WP_126195939.1 EamA family transporter -
ELY19_RS09310 1857556..1858446 + 891 WP_126195940.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-46)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14196.89 Da        Isoelectric Point: 4.3553

>T286502 WP_164711568.1 NZ_LR131273:c1853186-1852788 [Tsukamurella paurometabola]
MDTSALTKLIIAEQESDALTVWVAEQAEAHETLTTSDVGRIELMRTAARRDDDEIFDHARYVANWINGASVTEEIVAGAE
HIGPPSLRSLDAIHLASAVSIRELVSAFVSYDKRLLDAARAEGLPVVSPGAA

Download         Length: 399 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10737.54 Da        Isoelectric Point: 10.1401

>AT286502 WP_126195936.1 NZ_LR131273:c1853473-1853192 [Tsukamurella paurometabola]
MEQIGVRELRQHASKYLARVEAGEEIEVTNHGRLVARLVPVNEKERQFRELVAAGKIKPAKHPFDLEKLVAMRRPLKPGE
KSLTQILLEMREE

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References