286490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3756980..3757598 Replicon chromosome
Accession NZ_LR130564
Organism Escherichia coli strain MS14387 isolate MS14387

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FVE81_RS18455 Protein ID WP_001291435.1
Coordinates 3757380..3757598 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FVE81_RS18450 Protein ID WP_000344800.1
Coordinates 3756980..3757354 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE81_RS18440 3752069..3753262 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FVE81_RS18445 3753285..3756434 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
FVE81_RS18450 3756980..3757354 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FVE81_RS18455 3757380..3757598 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FVE81_RS18460 3757770..3758321 + 552 WP_000102559.1 maltose O-acetyltransferase -
FVE81_RS18465 3758437..3758907 + 471 WP_000136192.1 YlaC family protein -
FVE81_RS18470 3759071..3760621 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FVE81_RS18475 3760663..3761016 - 354 WP_000878140.1 DUF1428 domain-containing protein -
FVE81_RS18485 3761395..3761706 + 312 WP_000409911.1 MGMT family protein -
FVE81_RS18490 3761737..3762309 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286490 WP_001291435.1 NZ_LR130564:3757380-3757598 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286490 WP_000344800.1 NZ_LR130564:3756980-3757354 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References