Detailed information of TA system TA028649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 658389..658829
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: TVNIR_RS03310
• Protein ID: WP_211263174.1
• Coordinates: 658644..658829 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: L0DVQ3
• Locus tag: TVNIR_RS03305
• Protein ID: WP_015257556.1
• Coordinates: 658389..658598 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS03280	653742..654092	+	351	WP_043739202.1	type II toxin-antitoxin system MqsR family toxin	-
TVNIR_RS03285	654092..654661	+	570	WP_043739204.1	type II toxin-antitoxin system MqsA family antitoxin	-
TVNIR_RS19975	654658..655122	+	465	WP_169794285.1	protein-export chaperone SecB	-
TVNIR_RS18615	655455..655574	+	120	WP_157092328.1	phosphoglycolate phosphatase	-
TVNIR_RS03295	655579..656352	+	774	WP_015257554.1	YdcF family protein	-
TVNIR_RS03300	656578..657933	+	1356	WP_015257555.1	plasmid recombination protein	-
TVNIR_RS18620	657983..658273	+	291	Protein_671	YdcF family protein	-
TVNIR_RS03305	658389..658598	+	210	WP_015257556.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TVNIR_RS03310	658644..658829	+	186	WP_211263174.1	type II toxin-antitoxin system HicA family toxin	Toxin
TVNIR_RS03315	658854..659177	+	324	WP_157092175.1	YdcF family protein	-
TVNIR_RS03320	659524..659868	+	345	WP_043739212.1	nucleotidyltransferase domain-containing protein	-
TVNIR_RS03325	659865..660254	+	390	WP_015257560.1	HEPN domain-containing protein	-
TVNIR_RS03330	660551..660787	+	237	WP_015257561.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
TVNIR_RS03335	660787..661221	+	435	WP_015257562.1	type II toxin-antitoxin system VapC family toxin	-
TVNIR_RS03340	661237..661668	-	432	WP_015257563.1	PIN domain-containing protein	-
TVNIR_RS03345	661655..661885	-	231	WP_015257564.1	ribbon-helix-helix protein, CopG family	-
TVNIR_RS03350	662024..662335	+	312	WP_015257565.1	YdcF family protein	-
TVNIR_RS03355	662395..662733	+	339	WP_015257566.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	bplB	634414..677813	43399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-51)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6915.93 Da
• Isoelectric Point: 11.3371

>T28649 WP_211263174.1 NC_019902:658644-658829 [Thioalkalivibrio nitratireducens DSM 14787]
ILLRLGFVEVRQRGSHKQFRHPDGRATTVPFHAGRDISTPLLRQIIKDIGLTPDDFLTNHG

Nucleotide

• Length: 186 bp

>T28649 NC_019902:658644-658829 [Thioalkalivibrio nitratireducens DSM 14787]
ATCCTTTTGCGGCTCGGTTTCGTCGAGGTTCGCCAAAGAGGTTCGCATAAGCAATTCAGGCATCCGGATGGAAGAGCGAC
AACGGTGCCATTCCACGCCGGCCGGGACATCTCCACACCGTTGCTGCGGCAGATCATCAAGGATATCGGGCTCACCCCCG
ACGATTTTCTGACCAACCATGGATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7629.61 Da
• Isoelectric Point: 3.8770

>AT28649 WP_015257556.1 NC_019902:658389-658598 [Thioalkalivibrio nitratireducens DSM 14787]
MRQYSAVVERCPLTGYYVGFIPGFPGAHSQAETLDELQSNLKEVIEMLLEDGEPQLESEFVGVQQIAVA

Nucleotide

• Length: 210 bp

>AT28649 NC_019902:658389-658598 [Thioalkalivibrio nitratireducens DSM 14787]
ATGAGACAGTACTCTGCAGTCGTCGAACGCTGCCCGCTGACCGGGTATTACGTGGGCTTCATTCCCGGATTCCCTGGTGC
GCACAGTCAGGCGGAAACGTTGGACGAGTTACAAAGCAACCTTAAGGAAGTCATCGAGATGCTGCTGGAGGACGGCGAGC
CGCAGTTGGAATCCGAGTTCGTGGGAGTTCAACAGATCGCAGTTGCCTGA

Structures

Antitoxin

• AlphaFold DB: L0DVQ3