286489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3266527..3267232 Replicon chromosome
Accession NZ_LR130564
Organism Escherichia coli strain MS14387 isolate MS14387

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag FVE81_RS15975 Protein ID WP_000539521.1
Coordinates 3266527..3266913 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FVE81_RS15980 Protein ID WP_001280945.1
Coordinates 3266903..3267232 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE81_RS15955 3262531..3263157 + 627 WP_001295292.1 glutathione S-transferase GstB -
FVE81_RS15960 3263154..3264269 - 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
FVE81_RS15965 3264380..3264763 - 384 WP_000497137.1 biofilm formation regulator BssR -
FVE81_RS15970 3264976..3266301 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
FVE81_RS15975 3266527..3266913 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVE81_RS15980 3266903..3267232 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
FVE81_RS15985 3267302..3268630 - 1329 WP_000086879.1 GGDEF domain-containing protein -
FVE81_RS15990 3268638..3270986 - 2349 WP_001322378.1 EAL domain-containing protein -
FVE81_RS15995 3271164..3272075 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T286489 WP_000539521.1 NZ_LR130564:3266527-3266913 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT286489 WP_001280945.1 NZ_LR130564:3266903-3267232 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References