Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 801021..801822 Replicon chromosome
Accession NZ_LR130564
Organism Escherichia coli strain MS14387 isolate MS14387

Toxin (Protein)


Gene name yeeV Uniprot ID U9ZA48
Locus tag FVE81_RS03870 Protein ID WP_001513431.1
Coordinates 801021..801398 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID U9YYT7
Locus tag FVE81_RS03875 Protein ID WP_001513429.1
Coordinates 801445..801822 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE81_RS03845 797153..798136 - 984 WP_001329577.1 KpsF/GutQ family sugar-phosphate isomerase -
FVE81_RS03850 798946..799116 - 171 Protein_755 IS110 family transposase -
FVE81_RS03855 799459..800301 - 843 WP_001513432.1 DUF4942 domain-containing protein -
FVE81_RS03860 800386..800583 - 198 WP_001374283.1 DUF957 domain-containing protein -
FVE81_RS03865 800595..801024 - 430 Protein_758 hypothetical protein -
FVE81_RS03870 801021..801398 - 378 WP_001513431.1 TA system toxin CbtA family protein Toxin
FVE81_RS03875 801445..801822 - 378 WP_001513429.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FVE81_RS03880 801985..802206 - 222 WP_000692345.1 DUF987 domain-containing protein -
FVE81_RS03885 802275..802751 - 477 WP_001186726.1 RadC family protein -
FVE81_RS03890 802767..803252 - 486 WP_001513428.1 antirestriction protein -
FVE81_RS03895 803307..804125 - 819 WP_001513427.1 DUF945 domain-containing protein -
FVE81_RS25955 804206..804417 + 212 Protein_765 hypothetical protein -
FVE81_RS03910 804536..804991 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 801021..832000 30979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13941.80 Da        Isoelectric Point: 7.3225

>T286479 WP_001513431.1 NZ_LR130564:c801398-801021 [Escherichia coli]
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13688.48 Da        Isoelectric Point: 5.9505

>AT286479 WP_001513429.1 NZ_LR130564:c801822-801445 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZA48

Antitoxin

Source ID Structure
AlphaFold DB U9YYT7

References