Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4444878..4445473 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag EW037_RS21530 Protein ID WP_019842229.1
Coordinates 4444878..4445228 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag EW037_RS21535 Protein ID WP_001223213.1
Coordinates 4445222..4445473 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS21510 4440208..4441230 - 1023 WP_001550507.1 ABC transporter permease -
EW037_RS21515 4441244..4442746 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
EW037_RS21520 4442878..4443834 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EW037_RS21525 4444144..4444674 + 531 WP_000055075.1 inorganic diphosphatase -
EW037_RS21530 4444878..4445228 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
EW037_RS21535 4445222..4445473 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EW037_RS21540 4445685..4446026 - 342 WP_001596433.1 gamma-glutamylcyclotransferase -
EW037_RS21545 4446029..4449808 - 3780 WP_001596432.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T286472 WP_019842229.1 NZ_LR130562:c4445228-4444878 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT286472 WP_001223213.1 NZ_LR130562:c4445473-4445222 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References