286470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4312281..4313101 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EW037_RS20840 Protein ID WP_001054376.1
Coordinates 4312281..4312538 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag EW037_RS20845 Protein ID WP_000215866.1
Coordinates 4312550..4313101 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS20820 4307567..4308673 + 1107 WP_001044124.1 N-acetylneuraminate epimerase -
EW037_RS20825 4308738..4309718 + 981 WP_001765419.1 sialate O-acetylesterase -
EW037_RS20830 4310301..4311527 - 1227 Protein_4007 helicase YjhR -
EW037_RS20835 4311605..4311904 + 300 WP_024186563.1 GNAT family N-acetyltransferase -
EW037_RS20840 4312281..4312538 + 258 WP_001054376.1 hypothetical protein Toxin
EW037_RS20845 4312550..4313101 + 552 WP_000215866.1 N-acetyltransferase Antitoxin
EW037_RS20850 4313153..4313899 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EW037_RS20855 4314026..4314286 + 261 WP_000084876.1 hypothetical protein -
EW037_RS25615 4314324..4314440 + 117 Protein_4013 VOC family protein -
EW037_RS20860 4314685..4315806 + 1122 WP_000010835.1 M42 family metallopeptidase -
EW037_RS20865 4315803..4316081 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EW037_RS20870 4316093..4317406 + 1314 WP_000460846.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4301309..4321321 20012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T286470 WP_001054376.1 NZ_LR130562:4312281-4312538 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20493.64 Da        Isoelectric Point: 6.8758

>AT286470 WP_000215866.1 NZ_LR130562:4312550-4313101 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKETDLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References