Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 614913..615423 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | - |
| Locus tag | TVNIR_RS03085 | Protein ID | WP_043739186.1 |
| Coordinates | 615121..615423 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | L0DTP4 |
| Locus tag | TVNIR_RS03080 | Protein ID | WP_006748723.1 |
| Coordinates | 614913..615137 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS03020 | 609993..610313 | + | 321 | WP_015257503.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS03025 | 610310..610633 | + | 324 | WP_015257504.1 | addiction module antidote protein | - |
| TVNIR_RS03030 | 610785..610997 | + | 213 | WP_015257505.1 | type II toxin-antitoxin system HicA family toxin | - |
| TVNIR_RS03035 | 611007..611438 | + | 432 | WP_015257506.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS03040 | 611577..611828 | + | 252 | WP_015257507.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| TVNIR_RS03045 | 611937..612158 | + | 222 | WP_052316598.1 | hypothetical protein | - |
| TVNIR_RS18575 | 612271..612570 | + | 300 | WP_083499327.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS03055 | 612567..613058 | + | 492 | WP_043739181.1 | hypothetical protein | - |
| TVNIR_RS03060 | 613277..613714 | + | 438 | WP_211263171.1 | MarR family EPS-associated transcriptional regulator | - |
| TVNIR_RS03065 | 613905..614207 | + | 303 | WP_015257511.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS03070 | 614204..614488 | + | 285 | WP_043739183.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS03075 | 614485..614809 | + | 325 | Protein_622 | transcriptional regulator | - |
| TVNIR_RS03080 | 614913..615137 | + | 225 | WP_006748723.1 | TraY domain-containing protein | Antitoxin |
| TVNIR_RS03085 | 615121..615423 | + | 303 | WP_043739186.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TVNIR_RS03090 | 615576..615845 | + | 270 | WP_015257514.1 | BrnT family toxin | - |
| TVNIR_RS18580 | 615859..616128 | + | 270 | WP_015257515.1 | BrnA antitoxin family protein | - |
| TVNIR_RS03095 | 616436..617005 | - | 570 | WP_211263140.1 | hypothetical protein | - |
| TVNIR_RS03100 | 617089..617343 | + | 255 | WP_015257517.1 | HicA family toxin-antitoxin system toxin component | - |
| TVNIR_RS03105 | 617333..617668 | + | 336 | WP_015257518.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS03110 | 617900..618337 | + | 438 | WP_211263172.1 | MarR family EPS-associated transcriptional regulator | - |
| TVNIR_RS03115 | 618491..619801 | + | 1311 | WP_015257520.1 | nucleotide sugar dehydrogenase | - |
| TVNIR_RS03120 | 619981..620250 | + | 270 | WP_006749145.1 | BrnT family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fcl / fcl / gmd | 592815..626841 | 34026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11896.66 Da Isoelectric Point: 11.1136
>T28647 WP_043739186.1 NC_019902:615121-615423 [Thioalkalivibrio nitratireducens DSM 14787]
MSWTIEFDRRVEKDLRALDKPSARRILKYLNERIAPLDDPRRLGKSLTGELGEYWRYRVGPYRIIASIEDERFRVLVVRV
AHRNAVYRQGLGARNDRPSR
MSWTIEFDRRVEKDLRALDKPSARRILKYLNERIAPLDDPRRLGKSLTGELGEYWRYRVGPYRIIASIEDERFRVLVVRV
AHRNAVYRQGLGARNDRPSR
Download Length: 303 bp
>T28647 NC_019902:615121-615423 [Thioalkalivibrio nitratireducens DSM 14787]
TTGAGCTGGACGATTGAATTTGATCGCCGCGTGGAGAAAGACCTGCGTGCATTGGACAAGCCATCGGCACGCCGGATTCT
GAAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCGCGGCGTCTGGGCAAGTCGCTGACTGGGGAATTGGGCGAAT
ACTGGCGCTACCGCGTGGGTCCGTACCGAATCATTGCATCGATAGAGGATGAACGGTTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGCGGTCTATCGCCAGGGCCTCGGGGCTCGCAATGACAGGCCGTCGCGATGA
TTGAGCTGGACGATTGAATTTGATCGCCGCGTGGAGAAAGACCTGCGTGCATTGGACAAGCCATCGGCACGCCGGATTCT
GAAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCGCGGCGTCTGGGCAAGTCGCTGACTGGGGAATTGGGCGAAT
ACTGGCGCTACCGCGTGGGTCCGTACCGAATCATTGCATCGATAGAGGATGAACGGTTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGCGGTCTATCGCCAGGGCCTCGGGGCTCGCAATGACAGGCCGTCGCGATGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8587.70 Da Isoelectric Point: 4.6899
>AT28647 WP_006748723.1 NC_019902:614913-615137 [Thioalkalivibrio nitratireducens DSM 14787]
MLALRLPEDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSGETVSMDEMRRRLELDD
MLALRLPEDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSGETVSMDEMRRRLELDD
Download Length: 225 bp
>AT28647 NC_019902:614913-615137 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCTCGCATTACGGCTTCCCGAGGATGTGGAAGAACGCCTGGCGGCCCTCGCCAAAGCCACAGGACGAAGCAAAAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATTTACCTGGCTGAACAGCGCCTGATCGATCACC
GCAAAGGAAGCGGCGAGACAGTCTCCATGGACGAAATGAGGCGCCGGCTTGAGCTGGACGATTGA
ATGCTCGCATTACGGCTTCCCGAGGATGTGGAAGAACGCCTGGCGGCCCTCGCCAAAGCCACAGGACGAAGCAAAAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATTTACCTGGCTGAACAGCGCCTGATCGATCACC
GCAAAGGAAGCGGCGAGACAGTCTCCATGGACGAAATGAGGCGCCGGCTTGAGCTGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|