286465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3686547..3687165 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EW037_RS17895 Protein ID WP_001291435.1
Coordinates 3686947..3687165 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EW037_RS17890 Protein ID WP_000344800.1
Coordinates 3686547..3686921 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS17880 3681636..3682829 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EW037_RS17885 3682852..3686001 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
EW037_RS17890 3686547..3686921 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EW037_RS17895 3686947..3687165 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EW037_RS17900 3687337..3687888 + 552 WP_000102564.1 maltose O-acetyltransferase -
EW037_RS17905 3688004..3688474 + 471 WP_000136192.1 YlaC family protein -
EW037_RS17910 3688638..3690188 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EW037_RS17915 3690230..3690583 - 354 WP_001550741.1 DUF1428 family protein -
EW037_RS17925 3690962..3691273 + 312 WP_000409911.1 MGMT family protein -
EW037_RS17930 3691304..3691876 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286465 WP_001291435.1 NZ_LR130562:3686947-3687165 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286465 WP_000344800.1 NZ_LR130562:3686547-3686921 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References