Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3029244..3030028 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag EW037_RS14890 Protein ID WP_001595626.1
Coordinates 3029534..3030028 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag EW037_RS14885 Protein ID WP_001110447.1
Coordinates 3029244..3029537 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS14870 3024394..3025353 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
EW037_RS14880 3025926..3029111 + 3186 WP_001595627.1 ribonuclease E -
EW037_RS14885 3029244..3029537 + 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
EW037_RS14890 3029534..3030028 + 495 WP_001595626.1 GNAT family N-acetyltransferase Toxin
EW037_RS14895 3030123..3031076 - 954 WP_001212768.1 flagellar hook-associated protein FlgL -
EW037_RS14900 3031088..3032731 - 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
EW037_RS14905 3032797..3033738 - 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
EW037_RS14910 3033738..3034835 - 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18065.97 Da        Isoelectric Point: 8.2617

>T286463 WP_001595626.1 NZ_LR130562:3029534-3030028 [Escherichia coli]
MIQAPEPLIARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT286463 WP_001110447.1 NZ_LR130562:3029244-3029537 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References