286462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2647658..2648296 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EW037_RS12935 Protein ID WP_000813794.1
Coordinates 2648120..2648296 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EW037_RS12930 Protein ID WP_001270286.1
Coordinates 2647658..2648074 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS12910 2642810..2643751 - 942 WP_001251315.1 ABC transporter permease -
EW037_RS12915 2643752..2644765 - 1014 WP_001595723.1 ABC transporter ATP-binding protein -
EW037_RS12920 2644783..2645928 - 1146 WP_000047452.1 ABC transporter substrate-binding protein -
EW037_RS12925 2646173..2647579 - 1407 WP_001595721.1 PLP-dependent aminotransferase family protein -
EW037_RS12930 2647658..2648074 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EW037_RS12935 2648120..2648296 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EW037_RS12940 2648518..2648748 + 231 WP_000494241.1 YncJ family protein -
EW037_RS12945 2648840..2650801 - 1962 WP_001595719.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EW037_RS12950 2650874..2651410 - 537 WP_001595717.1 DNA-binding transcriptional regulator SutR -
EW037_RS12955 2651463..2652674 + 1212 WP_071600865.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T286462 WP_000813794.1 NZ_LR130562:c2648296-2648120 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT286462 WP_001270286.1 NZ_LR130562:c2648074-2647658 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References