Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2546323..2547911 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EW037_RS12475 Protein ID WP_001595766.1
Coordinates 2546589..2547911 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EW037_RS12470 Protein ID WP_001296726.1
Coordinates 2546323..2546589 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS12470 2546323..2546589 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EW037_RS12475 2546589..2547911 + 1323 WP_001595766.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
EW037_RS12480 2548309..2549208 - 900 WP_001057776.1 LysR family transcriptional regulator -
EW037_RS12485 2549348..2549656 + 309 WP_001221046.1 hypothetical protein -
EW037_RS12490 2549665..2550354 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
EW037_RS12495 2550428..2551375 + 948 WP_000854796.1 aldo/keto reductase -
EW037_RS25480 2551478..2551633 + 156 WP_001322415.1 hypothetical protein -
EW037_RS12500 2551593..2552012 + 420 WP_001322416.1 amidohydrolase family protein -
EW037_RS12505 2551963..2552154 + 192 WP_001469139.1 amidohydrolase family protein -
EW037_RS12510 2552305..2552877 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49370.02 Da        Isoelectric Point: 8.5830

>T286461 WP_001595766.1 NZ_LR130562:2546589-2547911 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGVNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT286461 WP_001296726.1 NZ_LR130562:2546323-2546589 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References