Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 970650..971304 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag EW037_RS04765 Protein ID WP_000244781.1
Coordinates 970897..971304 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EW037_RS04760 Protein ID WP_000354046.1
Coordinates 970650..970916 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS04740 966738..968171 - 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -
EW037_RS04745 968216..968527 + 312 WP_001525592.1 N(4)-acetylcytidine aminohydrolase -
EW037_RS04750 968691..969350 + 660 WP_000250275.1 hemolysin III family protein -
EW037_RS04755 969427..970407 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
EW037_RS04760 970650..970916 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EW037_RS04765 970897..971304 + 408 WP_000244781.1 protein YgfX Toxin
EW037_RS04770 971344..971865 - 522 WP_001055874.1 flavodoxin FldB -
EW037_RS04775 971977..972873 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EW037_RS04780 972898..973608 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EW037_RS04785 973614..975347 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T286453 WP_000244781.1 NZ_LR130562:970897-971304 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT286453 WP_000354046.1 NZ_LR130562:970650-970916 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References