Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 842210..843005 Replicon chromosome
Accession NZ_LR130562
Organism Escherichia coli strain MS14384 isolate MS14384

Toxin (Protein)


Gene name yeeV Uniprot ID A0A658LKE6
Locus tag EW037_RS04035 Protein ID WP_001596171.1
Coordinates 842210..842584 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EW037_RS04040 Protein ID WP_001596170.1
Coordinates 842631..843005 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW037_RS04010 838280..839263 - 984 WP_129766513.1 KpsF/GutQ family sugar-phosphate isomerase -
EW037_RS04015 840074..840244 - 171 Protein_778 IS110 family transposase -
EW037_RS04020 840586..841428 - 843 Protein_779 DUF4942 domain-containing protein -
EW037_RS04025 841513..841710 - 198 WP_001596173.1 DUF957 domain-containing protein -
EW037_RS04030 841722..842213 - 492 WP_001596172.1 hypothetical protein -
EW037_RS04035 842210..842584 - 375 WP_001596171.1 TA system toxin CbtA family protein Toxin
EW037_RS04040 842631..843005 - 375 WP_001596170.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EW037_RS04045 843168..843389 - 222 WP_000692323.1 DUF987 domain-containing protein -
EW037_RS04050 843452..843928 - 477 WP_001186726.1 RadC family protein -
EW037_RS04055 843944..844396 - 453 WP_096035156.1 antirestriction protein -
EW037_RS25415 845628..845690 - 63 Protein_788 antirestriction protein -
EW037_RS04065 845782..846264 - 483 Protein_789 DUF932 domain-containing protein -
EW037_RS04070 846388..846621 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 840074..845561 5487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14161.14 Da        Isoelectric Point: 6.7041

>T286452 WP_001596171.1 NZ_LR130562:c842584-842210 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYELVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13813.62 Da        Isoelectric Point: 6.7387

>AT286452 WP_001596170.1 NZ_LR130562:c843005-842631 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658LKE6

Antitoxin

Source ID Structure

References