Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 608061..608571 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | L0DTM0 |
| Locus tag | TVNIR_RS03000 | Protein ID | WP_015257498.1 |
| Coordinates | 608269..608571 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | L0DRX8 |
| Locus tag | TVNIR_RS02995 | Protein ID | WP_015257497.1 |
| Coordinates | 608061..608285 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS02950 | 603974..604294 | + | 321 | WP_015257488.1 | helix-turn-helix domain-containing protein | - |
| TVNIR_RS02955 | 604337..604513 | + | 177 | Protein_596 | transcriptional regulator | - |
| TVNIR_RS02960 | 604654..604956 | + | 303 | WP_015257490.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS18560 | 604962..605174 | + | 213 | Protein_598 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS02965 | 605242..605469 | + | 228 | WP_015257491.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02970 | 605459..605899 | + | 441 | WP_015257492.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS19540 | 606266..606382 | + | 117 | WP_211263170.1 | winged helix-turn-helix transcriptional regulator | - |
| TVNIR_RS02980 | 606478..606606 | + | 129 | Protein_602 | GDP-L-fucose synthase | - |
| TVNIR_RS19545 | 606728..607345 | + | 618 | WP_052316597.1 | DUF433 domain-containing protein | - |
| TVNIR_RS02990 | 607329..607706 | + | 378 | WP_043739172.1 | DUF5615 family PIN-like protein | - |
| TVNIR_RS02995 | 608061..608285 | + | 225 | WP_015257497.1 | TraY domain-containing protein | Antitoxin |
| TVNIR_RS03000 | 608269..608571 | + | 303 | WP_015257498.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TVNIR_RS03005 | 608724..608993 | + | 270 | WP_015257499.1 | BrnT family toxin | - |
| TVNIR_RS03010 | 609007..609276 | + | 270 | WP_015257500.1 | BrnA antitoxin family protein | - |
| TVNIR_RS19970 | 609454..609627 | + | 174 | WP_015257501.1 | hypothetical protein | - |
| TVNIR_RS03015 | 609617..609829 | + | 213 | WP_043739178.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS03020 | 609993..610313 | + | 321 | WP_015257503.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS03025 | 610310..610633 | + | 324 | WP_015257504.1 | addiction module antidote protein | - |
| TVNIR_RS03030 | 610785..610997 | + | 213 | WP_015257505.1 | type II toxin-antitoxin system HicA family toxin | - |
| TVNIR_RS03035 | 611007..611438 | + | 432 | WP_015257506.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS03040 | 611577..611828 | + | 252 | WP_015257507.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| TVNIR_RS03045 | 611937..612158 | + | 222 | WP_052316598.1 | hypothetical protein | - |
| TVNIR_RS18575 | 612271..612570 | + | 300 | WP_083499327.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS03055 | 612567..613058 | + | 492 | WP_043739181.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fcl / fcl / gmd | 592815..626841 | 34026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11953.72 Da Isoelectric Point: 11.1136
>T28645 WP_015257498.1 NC_019902:608269-608571 [Thioalkalivibrio nitratireducens DSM 14787]
MSWTIEFDRRVEKDLRALDKPSARRILKYLNERIAPLDDPRRLGKSLTGELGEYWRYRVGPYRIIASIEDQRFRVLVVRV
AHRNEVYRQGLGARNDRPSR
MSWTIEFDRRVEKDLRALDKPSARRILKYLNERIAPLDDPRRLGKSLTGELGEYWRYRVGPYRIIASIEDQRFRVLVVRV
AHRNEVYRQGLGARNDRPSR
Download Length: 303 bp
>T28645 NC_019902:608269-608571 [Thioalkalivibrio nitratireducens DSM 14787]
TTGAGTTGGACGATTGAATTTGATCGCCGCGTCGAGAAAGACCTGCGTGCATTGGACAAGCCATCGGCACGCCGGATTCT
GAAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCACGGCGTCTGGGCAAGTCGCTCACCGGGGAATTGGGCGAAT
ACTGGCGCTACCGCGTGGGCCCGTACCGAATCATCGCATCGATAGAGGATCAACGGTTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGAGGTCTATCGCCAGGGCCTCGGGGCTCGCAATGACAGGCCGTCGCGATGA
TTGAGTTGGACGATTGAATTTGATCGCCGCGTCGAGAAAGACCTGCGTGCATTGGACAAGCCATCGGCACGCCGGATTCT
GAAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCACGGCGTCTGGGCAAGTCGCTCACCGGGGAATTGGGCGAAT
ACTGGCGCTACCGCGTGGGCCCGTACCGAATCATCGCATCGATAGAGGATCAACGGTTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGAGGTCTATCGCCAGGGCCTCGGGGCTCGCAATGACAGGCCGTCGCGATGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8601.73 Da Isoelectric Point: 4.6899
>AT28645 WP_015257497.1 NC_019902:608061-608285 [Thioalkalivibrio nitratireducens DSM 14787]
MLALRLPEDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSAETVSMDEMRRRLELDD
MLALRLPEDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSAETVSMDEMRRRLELDD
Download Length: 225 bp
>AT28645 NC_019902:608061-608285 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCTCGCATTAAGGCTTCCCGAGGATGTGGAAGAACGCCTGGCGGCCCTCGCCAAGGCCACAGGTCGAAGCAAGAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATTTACCTGGCTGAGCAGCGCCTGATCGATCACC
GCAAAGGAAGCGCCGAGACAGTCTCCATGGATGAAATGAGGCGCCGGCTTGAGTTGGACGATTGA
ATGCTCGCATTAAGGCTTCCCGAGGATGTGGAAGAACGCCTGGCGGCCCTCGCCAAGGCCACAGGTCGAAGCAAGAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATTTACCTGGCTGAGCAGCGCCTGATCGATCACC
GCAAAGGAAGCGCCGAGACAGTCTCCATGGATGAAATGAGGCGCCGGCTTGAGTTGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|