Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/CC2985(antitoxin) |
| Location | 601625..602154 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | TVNIR_RS02935 | Protein ID | WP_043739169.1 |
| Coordinates | 601867..602154 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | L0DVF0 |
| Locus tag | TVNIR_RS02930 | Protein ID | WP_015257484.1 |
| Coordinates | 601625..601870 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS02885 | 597099..597326 | + | 228 | WP_015257474.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02890 | 597316..597756 | + | 441 | WP_015257475.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02895 | 597894..598154 | + | 261 | WP_157092171.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS18550 | 598141..598425 | + | 285 | Protein_583 | type II toxin-antitoxin system YafQ family toxin | - |
| TVNIR_RS02900 | 598431..599213 | + | 783 | WP_211263169.1 | UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) | - |
| TVNIR_RS02905 | 599262..599564 | + | 303 | WP_015257479.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS02910 | 599855..600067 | + | 213 | WP_043739165.1 | type II toxin-antitoxin system HicA family toxin | - |
| TVNIR_RS02915 | 600077..600508 | + | 432 | WP_015257481.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS02920 | 600815..601066 | + | 252 | WP_015257482.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02925 | 601070..601504 | + | 435 | WP_015257483.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02930 | 601625..601870 | + | 246 | WP_015257484.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| TVNIR_RS02935 | 601867..602154 | + | 288 | WP_043739169.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TVNIR_RS18555 | 602183..602293 | + | 111 | Protein_592 | transposase | - |
| TVNIR_RS02940 | 602413..602637 | + | 225 | WP_015257486.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS02945 | 602864..603817 | + | 954 | WP_015257487.1 | GDP-L-fucose synthase | - |
| TVNIR_RS02950 | 603974..604294 | + | 321 | WP_015257488.1 | helix-turn-helix domain-containing protein | - |
| TVNIR_RS02955 | 604337..604513 | + | 177 | Protein_596 | transcriptional regulator | - |
| TVNIR_RS02960 | 604654..604956 | + | 303 | WP_015257490.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS18560 | 604962..605174 | + | 213 | Protein_598 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS02965 | 605242..605469 | + | 228 | WP_015257491.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02970 | 605459..605899 | + | 441 | WP_015257492.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS19540 | 606266..606382 | + | 117 | WP_211263170.1 | winged helix-turn-helix transcriptional regulator | - |
| TVNIR_RS02980 | 606478..606606 | + | 129 | Protein_602 | GDP-L-fucose synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fcl / fcl / gmd | 592815..626841 | 34026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11054.40 Da Isoelectric Point: 6.1214
>T28644 WP_043739169.1 NC_019902:601867-602154 [Thioalkalivibrio nitratireducens DSM 14787]
VSFFTLSRSAEEDLIQIYLEGATSFGLDQAQRYHQRLSQAFEFLAENPQAAPVRQELSALIRVHPVGSHIVLYTIRDHDI
YILRIRHGHEDWLDH
VSFFTLSRSAEEDLIQIYLEGATSFGLDQAQRYHQRLSQAFEFLAENPQAAPVRQELSALIRVHPVGSHIVLYTIRDHDI
YILRIRHGHEDWLDH
Download Length: 288 bp
>T28644 NC_019902:601867-602154 [Thioalkalivibrio nitratireducens DSM 14787]
GTGAGTTTTTTTACCCTCAGTCGTTCAGCGGAAGAGGACCTGATTCAGATCTACCTGGAAGGCGCCACATCGTTCGGGCT
TGACCAGGCCCAACGCTATCACCAAAGGCTTTCTCAGGCGTTCGAGTTTCTTGCAGAGAATCCCCAAGCGGCCCCGGTGC
GGCAAGAACTGAGCGCCTTGATTCGTGTTCACCCGGTGGGCTCGCACATTGTGCTTTACACCATACGAGATCACGATATT
TACATCCTTCGGATTCGGCACGGTCATGAGGACTGGCTGGATCATTGA
GTGAGTTTTTTTACCCTCAGTCGTTCAGCGGAAGAGGACCTGATTCAGATCTACCTGGAAGGCGCCACATCGTTCGGGCT
TGACCAGGCCCAACGCTATCACCAAAGGCTTTCTCAGGCGTTCGAGTTTCTTGCAGAGAATCCCCAAGCGGCCCCGGTGC
GGCAAGAACTGAGCGCCTTGATTCGTGTTCACCCGGTGGGCTCGCACATTGTGCTTTACACCATACGAGATCACGATATT
TACATCCTTCGGATTCGGCACGGTCATGAGGACTGGCTGGATCATTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9043.17 Da Isoelectric Point: 5.0941
>AT28644 WP_015257484.1 NC_019902:601625-601870 [Thioalkalivibrio nitratireducens DSM 14787]
MATMNVSLPDAMKAWVDQRSRSGRYSNASDYVRDLIRRDQERSAKIAQIQAMVDEALATGEGQRTMDEIEAEALSRIAAP
K
MATMNVSLPDAMKAWVDQRSRSGRYSNASDYVRDLIRRDQERSAKIAQIQAMVDEALATGEGQRTMDEIEAEALSRIAAP
K
Download Length: 246 bp
>AT28644 NC_019902:601625-601870 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGCAACGATGAATGTTTCCCTACCCGATGCGATGAAAGCCTGGGTTGATCAGCGTTCTCGCTCAGGTCGATACAGTAA
CGCGAGTGATTATGTCCGTGACCTGATACGGCGCGATCAGGAACGTTCCGCCAAAATCGCCCAGATCCAGGCTATGGTGG
ACGAGGCGCTCGCCACTGGTGAGGGCCAGCGGACCATGGATGAAATCGAAGCCGAGGCGCTGTCCAGAATCGCCGCACCG
AAGTGA
ATGGCAACGATGAATGTTTCCCTACCCGATGCGATGAAAGCCTGGGTTGATCAGCGTTCTCGCTCAGGTCGATACAGTAA
CGCGAGTGATTATGTCCGTGACCTGATACGGCGCGATCAGGAACGTTCCGCCAAAATCGCCCAGATCCAGGCTATGGTGG
ACGAGGCGCTCGCCACTGGTGAGGGCCAGCGGACCATGGATGAAATCGAAGCCGAGGCGCTGTCCAGAATCGCCGCACCG
AAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|