Detailed information of TA system TA286437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4664615..4665603
• Replicon: chromosome
• Accession: NZ_LR130555
• Organism: Escherichia coli strain MS14385 isolate MS14385

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: EW040_RS22970
• Protein ID: WP_014640052.1
• Coordinates: 4664615..4665001 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: EW040_RS22975
• Protein ID: WP_000458584.1
• Coordinates: 4665031..4665603 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW040_RS22925	4659703..4659948	-	246	WP_000141753.1	hypothetical protein	-
EW040_RS22930	4660061..4660371	+	311	Protein_4419	hypothetical protein	-
EW040_RS22935	4660386..4660748	+	363	WP_000135682.1	hypothetical protein	-
EW040_RS22940	4660814..4661638	+	825	WP_089438609.1	DUF2303 family protein	-
EW040_RS22945	4661766..4662302	+	537	WP_000008200.1	5'-deoxynucleotidase	-
EW040_RS22950	4662293..4662655	+	363	WP_001565177.1	phage protein	-
EW040_RS22955	4662655..4663464	+	810	WP_000206745.1	hypothetical protein	-
EW040_RS22960	4663464..4664036	+	573	WP_001061348.1	3'-5' exoribonuclease	-
EW040_RS22965	4664073..4664354	+	282	WP_001093917.1	pyocin activator PrtN family protein	-
EW040_RS27595	4664402..4664575	-	174	WP_000390072.1	hypothetical protein	-
EW040_RS22970	4664615..4665001	-	387	WP_014640052.1	hypothetical protein	Toxin
EW040_RS22975	4665031..4665603	-	573	WP_000458584.1	SocA family protein	Antitoxin
EW040_RS22980	4665839..4665961	-	123	WP_001300034.1	hypothetical protein	-
EW040_RS22985	4666323..4667327	-	1005	WP_022646425.1	DUF2713 family protein	-
EW040_RS22990	4667645..4668160	+	516	WP_000416263.1	zinc uptake transcriptional repressor Zur	-
EW040_RS22995	4668202..4668411	-	210	WP_001296638.1	CsbD family protein	-
EW040_RS23000	4668527..4669852	-	1326	WP_001361471.1	MATE family efflux transporter DinF	-
EW040_RS23005	4669925..4670533	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4624254..4670533	46279
	-	inside	Prophage	-	espX4	4613895..4710203	96308

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T286437 WP_014640052.1 NZ_LR130555:c4665001-4664615 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT286437 WP_000458584.1 NZ_LR130555:c4665603-4665031 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5