Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4325000..4325832 | Replicon | chromosome |
| Accession | NZ_LR130555 | ||
| Organism | Escherichia coli strain MS14385 isolate MS14385 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0Q2Y5N3 |
| Locus tag | EW040_RS21120 | Protein ID | WP_001514886.1 |
| Coordinates | 4325000..4325374 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | EW040_RS21125 | Protein ID | WP_001295723.1 |
| Coordinates | 4325464..4325832 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EW040_RS27685 | 4322725..4322883 | - | 159 | WP_001467148.1 | hypothetical protein | - |
| EW040_RS21100 | 4322983..4323159 | - | 177 | WP_000839290.1 | DUF957 domain-containing protein | - |
| EW040_RS21105 | 4323176..4323538 | - | 363 | Protein_4077 | hypothetical protein | - |
| EW040_RS21110 | 4323632..4324860 | + | 1229 | WP_164930399.1 | IS3 family transposase | - |
| EW040_RS21115 | 4324785..4325003 | - | 219 | WP_001514887.1 | hypothetical protein | - |
| EW040_RS21120 | 4325000..4325374 | - | 375 | WP_001514886.1 | TA system toxin CbtA family protein | Toxin |
| EW040_RS21125 | 4325464..4325832 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EW040_RS21130 | 4325995..4326216 | - | 222 | WP_000692286.1 | DUF987 domain-containing protein | - |
| EW040_RS21135 | 4326279..4326755 | - | 477 | WP_001186774.1 | RadC family protein | - |
| EW040_RS21140 | 4326771..4327244 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| EW040_RS21150 | 4327586..4328404 | - | 819 | WP_001234729.1 | DUF945 domain-containing protein | - |
| EW040_RS21160 | 4328559..4328717 | - | 159 | WP_001323397.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13930.91 Da Isoelectric Point: 7.2909
>T286435 WP_001514886.1 NZ_LR130555:c4325374-4325000 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT286435 WP_001295723.1 NZ_LR130555:c4325832-4325464 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q2Y5N3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |