Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3779380..3779998 Replicon chromosome
Accession NZ_LR130555
Organism Escherichia coli strain MS14385 isolate MS14385

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EW040_RS18520 Protein ID WP_001291435.1
Coordinates 3779780..3779998 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EW040_RS18515 Protein ID WP_000344800.1
Coordinates 3779380..3779754 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW040_RS18505 3774469..3775662 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EW040_RS18510 3775685..3778834 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EW040_RS18515 3779380..3779754 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EW040_RS18520 3779780..3779998 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EW040_RS18525 3780170..3780721 + 552 WP_000102574.1 maltose O-acetyltransferase -
EW040_RS18530 3780837..3781307 + 471 WP_022645280.1 YlaC family protein -
EW040_RS18535 3781471..3783021 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EW040_RS18540 3783063..3783416 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EW040_RS18550 3783795..3784106 + 312 WP_000409911.1 MGMT family protein -
EW040_RS18555 3784137..3784709 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286431 WP_001291435.1 NZ_LR130555:3779780-3779998 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286431 WP_000344800.1 NZ_LR130555:3779380-3779754 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References