Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 596240..596750 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | L0DTJ5 |
| Locus tag | TVNIR_RS02880 | Protein ID | WP_015257473.1 |
| Coordinates | 596448..596750 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | L0DRV4 |
| Locus tag | TVNIR_RS02875 | Protein ID | WP_015257472.1 |
| Coordinates | 596240..596464 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS19535 | 592776..592982 | + | 207 | Protein_574 | GDP-L-fucose synthase | - |
| TVNIR_RS02860 | 593936..594817 | + | 882 | Protein_575 | beta-CASP domain protein | - |
| TVNIR_RS02865 | 594935..595201 | + | 267 | Protein_576 | BrnT family toxin | - |
| TVNIR_RS02870 | 595546..595917 | + | 372 | WP_015257471.1 | hypothetical protein | - |
| TVNIR_RS02875 | 596240..596464 | + | 225 | WP_015257472.1 | TraY domain-containing protein | Antitoxin |
| TVNIR_RS02880 | 596448..596750 | + | 303 | WP_015257473.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TVNIR_RS02885 | 597099..597326 | + | 228 | WP_015257474.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02890 | 597316..597756 | + | 441 | WP_015257475.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02895 | 597894..598154 | + | 261 | WP_157092171.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS18550 | 598141..598425 | + | 285 | Protein_583 | type II toxin-antitoxin system YafQ family toxin | - |
| TVNIR_RS02900 | 598431..599213 | + | 783 | WP_211263169.1 | UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) | - |
| TVNIR_RS02905 | 599262..599564 | + | 303 | WP_015257479.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| TVNIR_RS02910 | 599855..600067 | + | 213 | WP_043739165.1 | type II toxin-antitoxin system HicA family toxin | - |
| TVNIR_RS02915 | 600077..600508 | + | 432 | WP_015257481.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| TVNIR_RS02920 | 600815..601066 | + | 252 | WP_015257482.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02925 | 601070..601504 | + | 435 | WP_015257483.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fcl / fcl / gmd | 592815..626841 | 34026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11926.60 Da Isoelectric Point: 10.3224
>T28643 WP_015257473.1 NC_019902:596448-596750 [Thioalkalivibrio nitratireducens DSM 14787]
MSWTIEFDRRVEKDLRALDKPSARRILEYLNERIAPLDDPRRLGKSLTGELGEYWRYRLGPYRIIASIEDERLRVLVVRV
AHRNEVYRQGLGARDDRSSR
MSWTIEFDRRVEKDLRALDKPSARRILEYLNERIAPLDDPRRLGKSLTGELGEYWRYRLGPYRIIASIEDERLRVLVVRV
AHRNEVYRQGLGARDDRSSR
Download Length: 303 bp
>T28643 NC_019902:596448-596750 [Thioalkalivibrio nitratireducens DSM 14787]
TTGAGTTGGACGATTGAATTTGATCGCCGCGTCGAGAAAGACCTGCGTGCATTGGACAAGCCATCAGCACGCCGGATTCT
GGAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCGCGGCGTCTGGGCAAGTCGCTGACCGGGGAATTGGGCGAAT
ACTGGCGCTACCGCCTGGGTCCGTACCGAATCATTGCATCGATAGAAGATGAACGGCTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGAGGTCTATCGCCAGGGCCTCGGGGCTCGCGATGACAGGTCGTCGCGATAA
TTGAGTTGGACGATTGAATTTGATCGCCGCGTCGAGAAAGACCTGCGTGCATTGGACAAGCCATCAGCACGCCGGATTCT
GGAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCGCGGCGTCTGGGCAAGTCGCTGACCGGGGAATTGGGCGAAT
ACTGGCGCTACCGCCTGGGTCCGTACCGAATCATTGCATCGATAGAAGATGAACGGCTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGAGGTCTATCGCCAGGGCCTCGGGGCTCGCGATGACAGGTCGTCGCGATAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8573.68 Da Isoelectric Point: 4.6787
>AT28643 WP_015257472.1 NC_019902:596240-596464 [Thioalkalivibrio nitratireducens DSM 14787]
MLALRLPDDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSGETVSMDEMRRRLELDD
MLALRLPDDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSGETVSMDEMRRRLELDD
Download Length: 225 bp
>AT28643 NC_019902:596240-596464 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCTCGCATTACGGCTTCCTGATGATGTGGAAGAACGCCTGGCTGCCCTCGCCAAGGCCACCGGTAGAAGCAAAAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATTTACCTGGCTGAACAGCGCCTGATCGATCACC
GCAAAGGAAGCGGCGAGACAGTGTCCATGGATGAAATGAGGCGCCGGCTTGAGTTGGACGATTGA
ATGCTCGCATTACGGCTTCCTGATGATGTGGAAGAACGCCTGGCTGCCCTCGCCAAGGCCACCGGTAGAAGCAAAAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATTTACCTGGCTGAACAGCGCCTGATCGATCACC
GCAAAGGAAGCGGCGAGACAGTGTCCATGGATGAAATGAGGCGCCGGCTTGAGTTGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|