Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 71807..72342 Replicon plasmid 2
Accession NZ_LR130553
Organism Escherichia coli strain MS14386 isolate MS14386

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag EW035_RS23850 Protein ID WP_000222771.1
Coordinates 71807..72094 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag EW035_RS23855 Protein ID WP_001139206.1
Coordinates 72091..72342 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW035_RS23835 67414..70947 + 3534 WP_129753565.1 autotransporter outer membrane beta-barrel domain-containing protein -
EW035_RS23840 71122..71327 - 206 Protein_82 hypothetical protein -
EW035_RS23845 71317..71517 + 201 WP_000896262.1 DUF839 domain-containing protein -
EW035_RS23850 71807..72094 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EW035_RS23855 72091..72342 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW035_RS23870 74289..76106 + 1818 Protein_87 helicase -
EW035_RS23875 76140..76580 + 441 WP_023352064.1 hypothetical protein -
EW035_RS23880 76577..76825 + 249 WP_000747846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / floR / ant(3'')-Ia / sul3 / blaTEM-1B / aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / aac(3)-IId - 1..123043 123043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T286412 WP_000222771.1 NZ_LR130553:c72094-71807 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT286412 WP_001139206.1 NZ_LR130553:c72342-72091 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References