Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-VagC |
| Location | 496362..497029 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | L0DV27 |
| Locus tag | TVNIR_RS02385 | Protein ID | WP_015257375.1 |
| Coordinates | 496362..496793 (-) | Length | 144 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | L0DTA2 |
| Locus tag | TVNIR_RS02390 | Protein ID | WP_015257376.1 |
| Coordinates | 496790..497029 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS02335 | 491364..491786 | + | 423 | WP_043739108.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS02340 | 492167..492553 | - | 387 | WP_015257368.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02345 | 492553..492783 | - | 231 | WP_006746162.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02350 | 492997..493383 | - | 387 | WP_015257369.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02355 | 493367..493624 | - | 258 | WP_043739112.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02360 | 494041..494421 | + | 381 | WP_015257371.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS02365 | 494411..494845 | + | 435 | WP_015257372.1 | DUF86 domain-containing protein | - |
| TVNIR_RS02370 | 495035..495415 | - | 381 | WP_015257373.1 | helix-turn-helix transcriptional regulator | - |
| TVNIR_RS02375 | 495412..495669 | - | 258 | WP_043739114.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS02380 | 495888..496151 | - | 264 | WP_015257374.1 | hypothetical protein | - |
| TVNIR_RS02385 | 496362..496793 | - | 432 | WP_015257375.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| TVNIR_RS02390 | 496790..497029 | - | 240 | WP_015257376.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| TVNIR_RS02395 | 497238..497727 | - | 490 | Protein_480 | hypothetical protein | - |
| TVNIR_RS02400 | 498192..498491 | - | 300 | WP_015257378.1 | HigA family addiction module antidote protein | - |
| TVNIR_RS02405 | 498504..498782 | - | 279 | WP_015257379.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS02410 | 499004..499978 | - | 975 | WP_015257380.1 | hypothetical protein | - |
| TVNIR_RS02415 | 500561..500803 | - | 243 | WP_043739116.1 | hypothetical protein | - |
| TVNIR_RS02420 | 500803..501249 | - | 447 | WP_211263138.1 | putative toxin-antitoxin system toxin component, PIN family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 495888..509195 | 13307 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 144 a.a. Molecular weight: 15708.01 Da Isoelectric Point: 6.7230
>T28641 WP_015257375.1 NC_019902:c496793-496362 [Thioalkalivibrio nitratireducens DSM 14787]
VTDTPLFLLDTNILSDLVRHPQGIVKRGIERVGEHAVCTSIIAAAELRFGAAKRGSVALTEQVEKVLGAMRVEPLDLPSD
REYGRLRLQLEQTGQPIGPNDLLIAAHALALGATVVTDNQREFQRVPGLRVENWLQTNRPAEK
VTDTPLFLLDTNILSDLVRHPQGIVKRGIERVGEHAVCTSIIAAAELRFGAAKRGSVALTEQVEKVLGAMRVEPLDLPSD
REYGRLRLQLEQTGQPIGPNDLLIAAHALALGATVVTDNQREFQRVPGLRVENWLQTNRPAEK
Download Length: 432 bp
>T28641 NC_019902:c496793-496362 [Thioalkalivibrio nitratireducens DSM 14787]
GTGACGGACACGCCGCTTTTCCTACTGGACACCAACATCCTCTCCGATCTGGTTCGCCACCCTCAGGGAATCGTCAAACG
CGGGATCGAGAGGGTCGGTGAACACGCGGTCTGCACCTCCATCATCGCTGCTGCCGAACTACGGTTCGGTGCAGCGAAGC
GGGGATCCGTAGCGCTGACGGAGCAGGTGGAGAAGGTCCTTGGTGCCATGCGCGTAGAGCCGCTCGACCTACCCTCAGAC
CGCGAGTACGGGCGGCTCCGTCTGCAACTCGAGCAGACCGGACAGCCCATCGGCCCGAATGACCTCTTGATCGCGGCGCA
CGCCTTGGCACTCGGCGCCACGGTCGTCACCGACAACCAGCGAGAATTCCAGCGCGTGCCCGGACTGCGGGTGGAGAACT
GGCTCCAGACGAATCGGCCAGCTGAGAAGTAA
GTGACGGACACGCCGCTTTTCCTACTGGACACCAACATCCTCTCCGATCTGGTTCGCCACCCTCAGGGAATCGTCAAACG
CGGGATCGAGAGGGTCGGTGAACACGCGGTCTGCACCTCCATCATCGCTGCTGCCGAACTACGGTTCGGTGCAGCGAAGC
GGGGATCCGTAGCGCTGACGGAGCAGGTGGAGAAGGTCCTTGGTGCCATGCGCGTAGAGCCGCTCGACCTACCCTCAGAC
CGCGAGTACGGGCGGCTCCGTCTGCAACTCGAGCAGACCGGACAGCCCATCGGCCCGAATGACCTCTTGATCGCGGCGCA
CGCCTTGGCACTCGGCGCCACGGTCGTCACCGACAACCAGCGAGAATTCCAGCGCGTGCCCGGACTGCGGGTGGAGAACT
GGCTCCAGACGAATCGGCCAGCTGAGAAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9187.36 Da Isoelectric Point: 4.6899
>AT28641 WP_015257376.1 NC_019902:c497029-496790 [Thioalkalivibrio nitratireducens DSM 14787]
METTRHVRLFRNGRNQAVRIPREFELDTDEAVIYREDDRLVIEPVRRKGLLATLATLHDLEEEFPNIDSGLGALDDVRL
METTRHVRLFRNGRNQAVRIPREFELDTDEAVIYREDDRLVIEPVRRKGLLATLATLHDLEEEFPNIDSGLGALDDVRL
Download Length: 240 bp
>AT28641 NC_019902:c497029-496790 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGAAACCACCCGTCATGTCCGACTCTTCCGCAACGGCCGTAACCAAGCGGTCCGGATTCCGCGGGAGTTCGAACTGGA
CACAGACGAAGCCGTCATCTATCGGGAAGACGACCGCCTCGTGATCGAGCCCGTCCGGCGCAAGGGACTCCTTGCCACAC
TGGCCACACTGCACGATCTCGAAGAAGAGTTCCCCAATATTGATTCCGGGCTCGGCGCGCTGGACGACGTACGCCTGTGA
ATGGAAACCACCCGTCATGTCCGACTCTTCCGCAACGGCCGTAACCAAGCGGTCCGGATTCCGCGGGAGTTCGAACTGGA
CACAGACGAAGCCGTCATCTATCGGGAAGACGACCGCCTCGTGATCGAGCCCGTCCGGCGCAAGGGACTCCTTGCCACAC
TGGCCACACTGCACGATCTCGAAGAAGAGTTCCCCAATATTGATTCCGGGCTCGGCGCGCTGGACGACGTACGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|