Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3517079..3517697 Replicon chromosome
Accession NZ_LR130552
Organism Escherichia coli strain MS14386 isolate MS14386

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EW035_RS17010 Protein ID WP_001291435.1
Coordinates 3517479..3517697 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EW035_RS17005 Protein ID WP_000344800.1
Coordinates 3517079..3517453 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW035_RS16995 3512168..3513361 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EW035_RS17000 3513384..3516533 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EW035_RS17005 3517079..3517453 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EW035_RS17010 3517479..3517697 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EW035_RS17015 3517868..3518419 + 552 WP_000102556.1 maltose O-acetyltransferase -
EW035_RS17020 3518535..3519005 + 471 WP_000136192.1 YlaC family protein -
EW035_RS17025 3519169..3520719 + 1551 WP_024166621.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EW035_RS17030 3520761..3521114 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EW035_RS17040 3521493..3521804 + 312 WP_000409911.1 MGMT family protein -
EW035_RS17045 3521835..3522407 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286406 WP_001291435.1 NZ_LR130552:3517479-3517697 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286406 WP_000344800.1 NZ_LR130552:3517079-3517453 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References