Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-couple_hipB |
| Location | 495035..495669 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | TVNIR_RS02375 | Protein ID | WP_043739114.1 |
| Coordinates | 495412..495669 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | L0DRK3 |
| Locus tag | TVNIR_RS02370 | Protein ID | WP_015257373.1 |
| Coordinates | 495035..495415 (-) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS02330 | 490088..491152 | + | 1065 | WP_157092321.1 | GGDEF domain-containing protein | - |
| TVNIR_RS02335 | 491364..491786 | + | 423 | WP_043739108.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS02340 | 492167..492553 | - | 387 | WP_015257368.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02345 | 492553..492783 | - | 231 | WP_006746162.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02350 | 492997..493383 | - | 387 | WP_015257369.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02355 | 493367..493624 | - | 258 | WP_043739112.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS02360 | 494041..494421 | + | 381 | WP_015257371.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS02365 | 494411..494845 | + | 435 | WP_015257372.1 | DUF86 domain-containing protein | - |
| TVNIR_RS02370 | 495035..495415 | - | 381 | WP_015257373.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| TVNIR_RS02375 | 495412..495669 | - | 258 | WP_043739114.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TVNIR_RS02380 | 495888..496151 | - | 264 | WP_015257374.1 | hypothetical protein | - |
| TVNIR_RS02385 | 496362..496793 | - | 432 | WP_015257375.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS02390 | 496790..497029 | - | 240 | WP_015257376.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| TVNIR_RS02395 | 497238..497727 | - | 490 | Protein_480 | hypothetical protein | - |
| TVNIR_RS02400 | 498192..498491 | - | 300 | WP_015257378.1 | HigA family addiction module antidote protein | - |
| TVNIR_RS02405 | 498504..498782 | - | 279 | WP_015257379.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| TVNIR_RS02410 | 499004..499978 | - | 975 | WP_015257380.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9829.53 Da Isoelectric Point: 11.0608
>T28640 WP_043739114.1 NC_019902:c495669-495412 [Thioalkalivibrio nitratireducens DSM 14787]
MHQLRYRKAALKALMKLPADARQRIQEALRQLVADVDTARLDIKALQGRDGFRLRVGKWRVIYHRDDNAMIILVVDAGSR
GDIYK
MHQLRYRKAALKALMKLPADARQRIQEALRQLVADVDTARLDIKALQGRDGFRLRVGKWRVIYHRDDNAMIILVVDAGSR
GDIYK
Download Length: 258 bp
>T28640 NC_019902:c495669-495412 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCATCAACTCCGATACAGGAAAGCGGCGCTCAAGGCCCTCATGAAACTGCCGGCGGATGCACGACAGCGTATTCAGGA
GGCGCTGAGACAACTGGTCGCAGACGTGGACACGGCCAGGCTTGATATCAAGGCGCTTCAAGGCAGAGACGGATTCAGGC
TCAGGGTCGGCAAATGGCGGGTGATCTACCACAGGGACGACAACGCGATGATCATCCTGGTCGTTGATGCGGGTTCGAGA
GGAGACATTTACAAATGA
ATGCATCAACTCCGATACAGGAAAGCGGCGCTCAAGGCCCTCATGAAACTGCCGGCGGATGCACGACAGCGTATTCAGGA
GGCGCTGAGACAACTGGTCGCAGACGTGGACACGGCCAGGCTTGATATCAAGGCGCTTCAAGGCAGAGACGGATTCAGGC
TCAGGGTCGGCAAATGGCGGGTGATCTACCACAGGGACGACAACGCGATGATCATCCTGGTCGTTGATGCGGGTTCGAGA
GGAGACATTTACAAATGA
Antitoxin
Download Length: 127 a.a. Molecular weight: 14105.05 Da Isoelectric Point: 4.4393
>AT28640 WP_015257373.1 NC_019902:c495415-495035 [Thioalkalivibrio nitratireducens DSM 14787]
MNAQVQIIERDGQPEYAVVPIETYRRLLALAEDMEDIRAYDRAMAEISRGEDEILPAEVAERFLNGATQPLRIWREYRGL
TQQKLADATGVGKSYISQIEAGKKQPTVGVLQALSRALAVDMEDLV
MNAQVQIIERDGQPEYAVVPIETYRRLLALAEDMEDIRAYDRAMAEISRGEDEILPAEVAERFLNGATQPLRIWREYRGL
TQQKLADATGVGKSYISQIEAGKKQPTVGVLQALSRALAVDMEDLV
Download Length: 381 bp
>AT28640 NC_019902:c495415-495035 [Thioalkalivibrio nitratireducens DSM 14787]
ATGAATGCCCAGGTACAGATCATCGAGCGGGACGGGCAGCCGGAGTATGCGGTGGTGCCCATCGAAACCTATCGCCGATT
GCTGGCGCTGGCCGAGGACATGGAGGATATCCGAGCCTACGATCGCGCCATGGCGGAGATCAGCCGGGGCGAGGACGAGA
TATTGCCCGCCGAGGTAGCCGAACGATTCCTGAACGGCGCAACCCAGCCGTTGCGGATCTGGCGGGAGTATCGCGGCCTG
ACCCAACAAAAGCTTGCCGACGCCACCGGAGTCGGCAAGTCCTACATCTCGCAAATCGAAGCGGGAAAGAAGCAGCCCAC
TGTCGGGGTGTTGCAAGCATTGTCACGCGCACTGGCGGTGGACATGGAAGACCTGGTTTGA
ATGAATGCCCAGGTACAGATCATCGAGCGGGACGGGCAGCCGGAGTATGCGGTGGTGCCCATCGAAACCTATCGCCGATT
GCTGGCGCTGGCCGAGGACATGGAGGATATCCGAGCCTACGATCGCGCCATGGCGGAGATCAGCCGGGGCGAGGACGAGA
TATTGCCCGCCGAGGTAGCCGAACGATTCCTGAACGGCGCAACCCAGCCGTTGCGGATCTGGCGGGAGTATCGCGGCCTG
ACCCAACAAAAGCTTGCCGACGCCACCGGAGTCGGCAAGTCCTACATCTCGCAAATCGAAGCGGGAAAGAAGCAGCCCAC
TGTCGGGGTGTTGCAAGCATTGTCACGCGCACTGGCGGTGGACATGGAAGACCTGGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|