Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2732171..2733759 Replicon chromosome
Accession NZ_LR130548
Organism Klebsiella pneumoniae strain KPC2 isolate KPC2

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag EW042_RS13735 Protein ID WP_002904792.1
Coordinates 2732171..2733493 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag EW042_RS13740 Protein ID WP_002904790.1
Coordinates 2733493..2733759 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW042_RS13715 2727227..2729728 + 2502 WP_004151634.1 fimbrial biogenesis outer membrane usher protein -
EW042_RS13720 2729716..2730720 + 1005 WP_002904798.1 type 1 fimbrial protein -
EW042_RS13730 2730862..2732154 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EW042_RS13735 2732171..2733493 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
EW042_RS13740 2733493..2733759 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EW042_RS13745 2734025..2734351 - 327 WP_002904788.1 hydroxyisourate hydrolase -
EW042_RS13750 2734348..2734848 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EW042_RS13755 2734826..2736205 - 1380 WP_002904785.1 purine permease -
EW042_RS13760 2736551..2737705 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EW042_RS13765 2737686..2738609 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T286388 WP_002904792.1 NZ_LR130548:c2733493-2732171 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT286388 WP_002904790.1 NZ_LR130548:c2733759-2733493 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References