Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4518274..4518869 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag EW036_RS22750 Protein ID WP_000239579.1
Coordinates 4518274..4518624 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag EW036_RS22755 Protein ID WP_001223208.1
Coordinates 4518618..4518869 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS22730 4513720..4514742 - 1023 WP_001296689.1 ABC transporter permease -
EW036_RS22735 4514756..4516258 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
EW036_RS22740 4516398..4517354 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EW036_RS22745 4517664..4518194 + 531 WP_000055075.1 inorganic diphosphatase -
EW036_RS22750 4518274..4518624 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
EW036_RS22755 4518618..4518869 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EW036_RS22760 4519081..4519422 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
EW036_RS22765 4519425..4523204 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T286371 WP_000239579.1 NZ_LR130545:c4518624-4518274 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT286371 WP_001223208.1 NZ_LR130545:c4518869-4518618 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References