Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 21544..22148 | Replicon | chromosome |
| Accession | NC_019902 | ||
| Organism | Thioalkalivibrio nitratireducens DSM 14787 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | L0DRX3 |
| Locus tag | TVNIR_RS00145 | Protein ID | WP_015256908.1 |
| Coordinates | 21894..22148 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | TVNIR_RS00140 | Protein ID | WP_211263161.1 |
| Coordinates | 21544..21888 (-) | Length | 115 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TVNIR_RS00095 | 16938..17063 | - | 126 | Protein_19 | ATP-binding protein | - |
| TVNIR_RS00100 | 17100..17588 | - | 489 | WP_043738921.1 | DUF3368 domain-containing protein | - |
| TVNIR_RS00105 | 17570..17914 | - | 345 | WP_015256900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS00110 | 18189..18485 | - | 297 | Protein_22 | DUF4351 domain-containing protein | - |
| TVNIR_RS00115 | 18497..18913 | - | 417 | WP_043738924.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS00120 | 18900..19163 | - | 264 | WP_043738927.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| TVNIR_RS00125 | 19394..19801 | - | 408 | WP_043739938.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS00130 | 19998..20246 | + | 249 | WP_015256905.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TVNIR_RS00135 | 20239..20667 | + | 429 | WP_015256906.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| TVNIR_RS00140 | 21544..21888 | - | 345 | WP_211263161.1 | toxin-antitoxin system HicB family antitoxin | Antitoxin |
| TVNIR_RS00145 | 21894..22148 | - | 255 | WP_015256908.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| TVNIR_RS00150 | 22363..22785 | - | 423 | WP_015256909.1 | DUF86 domain-containing protein | - |
| TVNIR_RS00155 | 22785..23192 | - | 408 | WP_043738930.1 | nucleotidyltransferase domain-containing protein | - |
| TVNIR_RS00160 | 23862..24086 | + | 225 | WP_015256911.1 | antitoxin VapB | - |
| TVNIR_RS00165 | 24261..24527 | + | 267 | WP_083499307.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| TVNIR_RS00170 | 24527..24841 | + | 315 | WP_015256913.1 | CcdB family protein | - |
| TVNIR_RS00175 | 24911..25306 | - | 396 | WP_015256914.1 | type II toxin-antitoxin system VapC family toxin | - |
| TVNIR_RS00180 | 25311..25550 | - | 240 | WP_006746524.1 | hypothetical protein | - |
| TVNIR_RS00185 | 26082..26312 | + | 231 | WP_006746523.1 | type II toxin-antitoxin system PrlF family antitoxin | - |
| TVNIR_RS00190 | 26302..26646 | + | 345 | WP_006746522.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9433.87 Da Isoelectric Point: 10.5454
>T28637 WP_015256908.1 NC_019902:c22148-21894 [Thioalkalivibrio nitratireducens DSM 14787]
MSRAEKLIARFREQPSDFTWDELVRLLEALDYTQATAGSTGGSRRRFVHATAPTISLHKPHPGNVVKRYAMAALLRVLKE
EGLV
MSRAEKLIARFREQPSDFTWDELVRLLEALDYTQATAGSTGGSRRRFVHATAPTISLHKPHPGNVVKRYAMAALLRVLKE
EGLV
Download Length: 255 bp
>T28637 NC_019902:c22148-21894 [Thioalkalivibrio nitratireducens DSM 14787]
ATGAGTCGGGCCGAGAAACTGATCGCAAGGTTCCGGGAGCAGCCGAGCGATTTCACCTGGGACGAGTTGGTCCGCTTGCT
GGAAGCCCTGGATTACACACAGGCTACTGCAGGTAGCACGGGCGGCTCCCGACGACGATTCGTACACGCGACTGCGCCAA
CGATCTCGTTGCACAAACCCCACCCGGGCAATGTCGTGAAGCGGTATGCCATGGCGGCGTTGCTGCGGGTTCTGAAGGAG
GAGGGTCTGGTATGA
ATGAGTCGGGCCGAGAAACTGATCGCAAGGTTCCGGGAGCAGCCGAGCGATTTCACCTGGGACGAGTTGGTCCGCTTGCT
GGAAGCCCTGGATTACACACAGGCTACTGCAGGTAGCACGGGCGGCTCCCGACGACGATTCGTACACGCGACTGCGCCAA
CGATCTCGTTGCACAAACCCCACCCGGGCAATGTCGTGAAGCGGTATGCCATGGCGGCGTTGCTGCGGGTTCTGAAGGAG
GAGGGTCTGGTATGA
Antitoxin
Download Length: 115 a.a. Molecular weight: 13102.65 Da Isoelectric Point: 5.2202
>AT28637 WP_211263161.1 NC_019902:c21888-21544 [Thioalkalivibrio nitratireducens DSM 14787]
MLEYKGYLGSVDFSDEDEVFHGRLEFIRDLVTYEGTDARSLKQAFHEAVDDYLALCAEQGRTPDEPLKGSFNVRPGPDLH
RRAMLFARRRGLNLNTVVSDALREYLDQKDRVAH
MLEYKGYLGSVDFSDEDEVFHGRLEFIRDLVTYEGTDARSLKQAFHEAVDDYLALCAEQGRTPDEPLKGSFNVRPGPDLH
RRAMLFARRRGLNLNTVVSDALREYLDQKDRVAH
Download Length: 345 bp
>AT28637 NC_019902:c21888-21544 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCTCGAATACAAGGGTTACCTGGGCTCGGTCGACTTCAGCGACGAAGACGAGGTGTTTCATGGCCGCCTGGAGTTCAT
CCGCGACCTGGTCACTTACGAGGGAACCGACGCGAGGAGCCTGAAGCAAGCCTTCCACGAGGCCGTGGACGACTACCTTG
CGCTGTGTGCCGAACAGGGACGCACCCCCGACGAGCCACTCAAGGGCAGTTTCAACGTACGCCCCGGGCCCGATTTGCAC
CGGCGGGCCATGCTCTTCGCCCGGCGCAGGGGCCTGAACCTGAACACGGTAGTGAGCGATGCACTGCGCGAGTACCTGGA
CCAGAAGGATCGCGTCGCGCACTGA
ATGCTCGAATACAAGGGTTACCTGGGCTCGGTCGACTTCAGCGACGAAGACGAGGTGTTTCATGGCCGCCTGGAGTTCAT
CCGCGACCTGGTCACTTACGAGGGAACCGACGCGAGGAGCCTGAAGCAAGCCTTCCACGAGGCCGTGGACGACTACCTTG
CGCTGTGTGCCGAACAGGGACGCACCCCCGACGAGCCACTCAAGGGCAGTTTCAACGTACGCCCCGGGCCCGATTTGCAC
CGGCGGGCCATGCTCTTCGCCCGGCGCAGGGGCCTGAACCTGAACACGGTAGTGAGCGATGCACTGCGCGAGTACCTGGA
CCAGAAGGATCGCGTCGCGCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|