286369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4384727..4385547 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag EW036_RS22015 Protein ID WP_001054379.1
Coordinates 4384727..4384984 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag EW036_RS22020 Protein ID WP_000123957.1
Coordinates 4384996..4385547 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS21995 4380274..4381254 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EW036_RS22000 4381837..4382943 - 1107 Protein_4218 helicase YjhR -
EW036_RS22005 4383006..4384153 + 1148 WP_085949154.1 IS3-like element ISEc52 family transposase -
EW036_RS22010 4384186..4384350 + 165 Protein_4220 GNAT family N-acetyltransferase -
EW036_RS22015 4384727..4384984 + 258 WP_001054379.1 YjhX family toxin Toxin
EW036_RS22020 4384996..4385547 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
EW036_RS22025 4385599..4386345 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
EW036_RS22030 4386473..4386733 + 261 WP_000077645.1 hypothetical protein -
EW036_RS26750 4386771..4386887 + 117 Protein_4225 VOC family protein -
EW036_RS22035 4387132..4388253 + 1122 WP_000010833.1 M42 family metallopeptidase -
EW036_RS22040 4388250..4388528 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EW036_RS22045 4388540..4389853 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 4373348..4393768 20420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T286369 WP_001054379.1 NZ_LR130545:4384727-4384984 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT286369 WP_000123957.1 NZ_LR130545:4384996-4385547 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References