286367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4225304..4225824 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag EW036_RS21245 Protein ID WP_001160964.1
Coordinates 4225304..4225588 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag EW036_RS21250 Protein ID WP_000125566.1
Coordinates 4225591..4225824 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS21220 4220949..4222235 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
EW036_RS21225 4222235..4223224 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
EW036_RS21230 4223221..4224042 + 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
EW036_RS21235 4224045..4224422 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
EW036_RS21240 4224429..4225277 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
EW036_RS21245 4225304..4225588 - 285 WP_001160964.1 CcdB family protein Toxin
EW036_RS21250 4225591..4225824 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EW036_RS21255 4225910..4226389 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
EW036_RS21260 4226581..4228443 - 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
EW036_RS21265 4228436..4228966 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
EW036_RS21270 4229074..4230405 - 1332 WP_001183209.1 MFS transporter -
EW036_RS21275 4230464..4230751 - 288 WP_000203744.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T286367 WP_001160964.1 NZ_LR130545:c4225588-4225304 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT286367 WP_000125566.1 NZ_LR130545:c4225824-4225591 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References