Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1039278..1039932 Replicon chromosome
Accession NZ_LR130545
Organism Escherichia coli strain B36 isolate B36

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag EW036_RS05210 Protein ID WP_000244765.1
Coordinates 1039525..1039932 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag EW036_RS05205 Protein ID WP_000354050.1
Coordinates 1039278..1039544 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW036_RS05185 1035366..1036799 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
EW036_RS05190 1036844..1037155 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
EW036_RS05195 1037319..1037978 + 660 WP_000250275.1 hemolysin III family protein -
EW036_RS05200 1038055..1039035 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
EW036_RS05205 1039278..1039544 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
EW036_RS05210 1039525..1039932 + 408 WP_000244765.1 protein YgfX Toxin
EW036_RS05215 1039972..1040493 - 522 WP_001055874.1 flavodoxin FldB -
EW036_RS05220 1040605..1041501 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EW036_RS05225 1041526..1042236 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EW036_RS05230 1042242..1043975 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T286352 WP_000244765.1 NZ_LR130545:1039525-1039932 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT286352 WP_000354050.1 NZ_LR130545:1039278-1039544 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References