Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
Location | 889783..891064 | Replicon | chromosome |
Accession | NZ_LR130545 | ||
Organism | Escherichia coli strain B36 isolate B36 |
Toxin (Protein)
Gene name | sanaT | Uniprot ID | A0A1X3JHM4 |
Locus tag | EW036_RS04340 | Protein ID | WP_001114681.1 |
Coordinates | 889783..890676 (-) | Length | 298 a.a. |
Antitoxin (Protein)
Gene name | sanaA | Uniprot ID | V0YCI1 |
Locus tag | EW036_RS04345 | Protein ID | WP_000208383.1 |
Coordinates | 890669..891064 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EW036_RS04320 | 884933..885916 | - | 984 | WP_001296394.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
EW036_RS04325 | 886542..887297 | - | 756 | Protein_836 | IS21-like element ISEc10 family helper ATPase IstB | - |
EW036_RS04330 | 887294..888793 | - | 1500 | WP_000174401.1 | IS21-like element ISEc10 family transposase | - |
EW036_RS04335 | 889142..889312 | - | 171 | Protein_838 | IS110 family transposase | - |
EW036_RS04340 | 889783..890676 | - | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
EW036_RS04345 | 890669..891064 | - | 396 | WP_000208383.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
EW036_RS04350 | 891133..891978 | - | 846 | WP_023281696.1 | DUF4942 domain-containing protein | - |
EW036_RS04355 | 892063..892260 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
EW036_RS04360 | 892277..892765 | - | 489 | WP_000761699.1 | hypothetical protein | - |
EW036_RS04365 | 892762..893139 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
EW036_RS04370 | 893216..893596 | - | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
EW036_RS04375 | 893646..894290 | - | 645 | WP_000094916.1 | hypothetical protein | - |
EW036_RS04380 | 894309..894530 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
EW036_RS04385 | 894593..895069 | - | 477 | WP_001186726.1 | RadC family protein | - |
EW036_RS04390 | 895085..895570 | - | 486 | WP_000849566.1 | antirestriction protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34298.40 Da Isoelectric Point: 5.9850
>T286350 WP_001114681.1 NZ_LR130545:c890676-889783 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT286350 WP_000208383.1 NZ_LR130545:c891064-890669 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X3JHM4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0YCI1 |