Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5022967..5024648 Replicon chromosome
Accession NZ_LR130544
Organism Klebsiella variicola strain 03-311-0071 isolate 03-311-0071

Toxin (Protein)


Gene name mosT Uniprot ID A0A7H4S924
Locus tag EW041_RS24530 Protein ID WP_012969143.1
Coordinates 5022967..5023884 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0B7GCX3
Locus tag EW041_RS24535 Protein ID WP_008807257.1
Coordinates 5023890..5024648 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW041_RS24510 5018273..5019793 + 1521 WP_008807253.1 sugar ABC transporter ATP-binding protein -
EW041_RS24515 5019790..5020788 + 999 WP_004206363.1 ribose ABC transporter permease -
EW041_RS24520 5020819..5021760 + 942 WP_012543155.1 ABC transporter substrate-binding protein -
EW041_RS24525 5021835..5022842 + 1008 WP_012969142.1 carbohydrate kinase family protein -
EW041_RS24530 5022967..5023884 - 918 WP_012969143.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EW041_RS24535 5023890..5024648 - 759 WP_008807257.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
EW041_RS24540 5024733..5025461 - 729 WP_008807258.1 response regulator transcription factor -
EW041_RS24545 5025734..5027881 + 2148 WP_110215877.1 formate dehydrogenase subunit alpha -
EW041_RS24550 5028059..5028745 + 687 WP_129766189.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34721.11 Da        Isoelectric Point: 5.4707

>T286346 WP_012969143.1 NZ_LR130544:c5023884-5022967 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28653.01 Da        Isoelectric Point: 10.1988

>AT286346 WP_008807257.1 NZ_LR130544:c5024648-5023890 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4S924

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7GCX3

References