Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2718821..2720409 Replicon chromosome
Accession NZ_LR130544
Organism Klebsiella variicola strain 03-311-0071 isolate 03-311-0071

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EW041_RS13420 Protein ID WP_044643526.1
Coordinates 2718821..2720143 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag EW041_RS13425 Protein ID WP_008804920.1
Coordinates 2720143..2720409 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW041_RS13405 2713886..2716387 + 2502 WP_129765873.1 fimbrial biogenesis outer membrane usher protein -
EW041_RS13410 2716375..2717379 + 1005 WP_110221475.1 type 1 fimbrial protein -
EW041_RS13415 2717512..2718804 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
EW041_RS13420 2718821..2720143 - 1323 WP_044643526.1 type II toxin-antitoxin system HipA family toxin Toxin
EW041_RS13425 2720143..2720409 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EW041_RS13430 2720675..2721001 - 327 WP_129765874.1 hydroxyisourate hydrolase -
EW041_RS13435 2720998..2721498 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EW041_RS13440 2721476..2722855 - 1380 WP_129765875.1 purine permease -
EW041_RS13445 2723201..2724355 + 1155 WP_050887171.1 FAD-dependent urate hydroxylase HpxO -
EW041_RS13450 2724336..2725259 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48939.32 Da        Isoelectric Point: 7.9109

>T286342 WP_044643526.1 NZ_LR130544:c2720143-2718821 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEVHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT286342 WP_008804920.1 NZ_LR130544:c2720409-2720143 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References